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Nucleotide Excision Repair Lesion-Recognition Protein Rad4 Captures a Pre-Flipped Partner Base in a Benzo[a]pyrene-Derived DNA Lesion: How Structure Impacts the Binding Pathway

[Image: see text] [Image: see text] The xeroderma pigmentosum C protein complex (XPC) recognizes a variety of environmentally induced DNA lesions and is the key in initiating their repair by the nucleotide excision repair (NER) pathway. When bound to a lesion, XPC flips two nucleotide pairs that inc...

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Detalles Bibliográficos
Autores principales:	Mu, Hong, Geacintov, Nicholas E., Min, Jung-Hyun, Zhang, Yingkai, Broyde, Suse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478902/ https://www.ncbi.nlm.nih.gov/pubmed/28460163 http://dx.doi.org/10.1021/acs.chemrestox.7b00074

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