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Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma

Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Met...

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Autores principales: Ke, Hung-Lung, Li, Wei-Ming, Lin, Hui-Hui, Hsu, Wei-Chi, Hsu, Ya-Ling, Chang, Lin-Li, Huang, Chun-Nung, Li, Ching-Chia, Chang, Hsin-Ping, Yeh, Hsin-Chih, Li, Chien-Feng, Wu, Wen-Jeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479127/
https://www.ncbi.nlm.nih.gov/pubmed/28638274
http://dx.doi.org/10.7150/ijms.15699
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author Ke, Hung-Lung
Li, Wei-Ming
Lin, Hui-Hui
Hsu, Wei-Chi
Hsu, Ya-Ling
Chang, Lin-Li
Huang, Chun-Nung
Li, Ching-Chia
Chang, Hsin-Ping
Yeh, Hsin-Chih
Li, Chien-Feng
Wu, Wen-Jeng
author_facet Ke, Hung-Lung
Li, Wei-Ming
Lin, Hui-Hui
Hsu, Wei-Chi
Hsu, Ya-Ling
Chang, Lin-Li
Huang, Chun-Nung
Li, Ching-Chia
Chang, Hsin-Ping
Yeh, Hsin-Chih
Li, Chien-Feng
Wu, Wen-Jeng
author_sort Ke, Hung-Lung
collection PubMed
description Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1α (HIF-1α) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1α was analyzed statistically. Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1α is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001). Conclusion: Both miR-210 and HIF-1α are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism.
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spelling pubmed-54791272017-06-21 Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma Ke, Hung-Lung Li, Wei-Ming Lin, Hui-Hui Hsu, Wei-Chi Hsu, Ya-Ling Chang, Lin-Li Huang, Chun-Nung Li, Ching-Chia Chang, Hsin-Ping Yeh, Hsin-Chih Li, Chien-Feng Wu, Wen-Jeng Int J Med Sci Research Paper Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1α (HIF-1α) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1α was analyzed statistically. Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1α is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001). Conclusion: Both miR-210 and HIF-1α are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism. Ivyspring International Publisher 2017-05-11 /pmc/articles/PMC5479127/ /pubmed/28638274 http://dx.doi.org/10.7150/ijms.15699 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Ke, Hung-Lung
Li, Wei-Ming
Lin, Hui-Hui
Hsu, Wei-Chi
Hsu, Ya-Ling
Chang, Lin-Li
Huang, Chun-Nung
Li, Ching-Chia
Chang, Hsin-Ping
Yeh, Hsin-Chih
Li, Chien-Feng
Wu, Wen-Jeng
Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma
title Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma
title_full Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma
title_fullStr Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma
title_full_unstemmed Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma
title_short Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma
title_sort hypoxia-regulated microrna-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479127/
https://www.ncbi.nlm.nih.gov/pubmed/28638274
http://dx.doi.org/10.7150/ijms.15699
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