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Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection

Aim: IgG4 is associated with a Th1-to-Th2 switch, which plays a vital role in metastasis, in patients with malignances; thus, we aimed to investigate its clinical significance in predicting hepatocellular carcinoma (HCC) recurrence in the present study. Methods: The correlation between serum IgG4:Ig...

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Autores principales: Wu, Jiong, Ma, Xiao-Lu, Tian, Lu, Zhang, Chun-Yan, Wang, Bei-Li, Hu, Yu-Yi, Gao, Xing-Hui, Zhou, Yan, Shen, Min-Na, Peng, Yin-Fei, Pan, Bai-Shen, Zhou, Jian, Fan, Jia, Yang, Xin-Rong, Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479238/
https://www.ncbi.nlm.nih.gov/pubmed/28638447
http://dx.doi.org/10.7150/jca.18030
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author Wu, Jiong
Ma, Xiao-Lu
Tian, Lu
Zhang, Chun-Yan
Wang, Bei-Li
Hu, Yu-Yi
Gao, Xing-Hui
Zhou, Yan
Shen, Min-Na
Peng, Yin-Fei
Pan, Bai-Shen
Zhou, Jian
Fan, Jia
Yang, Xin-Rong
Guo, Wei
author_facet Wu, Jiong
Ma, Xiao-Lu
Tian, Lu
Zhang, Chun-Yan
Wang, Bei-Li
Hu, Yu-Yi
Gao, Xing-Hui
Zhou, Yan
Shen, Min-Na
Peng, Yin-Fei
Pan, Bai-Shen
Zhou, Jian
Fan, Jia
Yang, Xin-Rong
Guo, Wei
author_sort Wu, Jiong
collection PubMed
description Aim: IgG4 is associated with a Th1-to-Th2 switch, which plays a vital role in metastasis, in patients with malignances; thus, we aimed to investigate its clinical significance in predicting hepatocellular carcinoma (HCC) recurrence in the present study. Methods: The correlation between serum IgG4:IgG ratio and recurrence was analyzed in a cohort of 195 patients undergoing curative resection in 2012. Another 100 patients were analyzed in a prospective independent cohort during 2012-2013 to validate the value of serum IgG4. Serum IgG4 and total IgG concentrations were measured with an automatic immune analyzer and the optimal cutoff value for serum IgG4 levels was determined by X-tile software. Results: Our data revealed that serum IgG4:IgG were significantly elevated in patients with tumor recurrence (P<0.05). A cutoff IgG:IgG4 ratio of 0.08 was set to stratify HCC patients into high (>0.08) and low (≤0.08) groups. High serum IgG4:IgG ratio correlated with significantly shorter time-to-recurrence (median 11.85 months vs. 39.20, P=0.005). Univariate and multivariate analyses demonstrated that serum IgG4:IgG ratio is an independent indicator of tumor recurrence and this retained its clinical significance even in conventional low-recurrence-risk subgroups, including patients with low α-fetoprotein and early-stage diseases. Conclusion: Our results demonstrated that elevated serum IgG4:IgG ratio is associated with poor clinical outcomes in HCC patients and therefore, and can serve as a novel prognostic predictor for HCC patients undergoing resection. Analyzing serum IgG4 would be useful to tailor individualized therapies for patients.
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spelling pubmed-54792382017-06-21 Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection Wu, Jiong Ma, Xiao-Lu Tian, Lu Zhang, Chun-Yan Wang, Bei-Li Hu, Yu-Yi Gao, Xing-Hui Zhou, Yan Shen, Min-Na Peng, Yin-Fei Pan, Bai-Shen Zhou, Jian Fan, Jia Yang, Xin-Rong Guo, Wei J Cancer Research Paper Aim: IgG4 is associated with a Th1-to-Th2 switch, which plays a vital role in metastasis, in patients with malignances; thus, we aimed to investigate its clinical significance in predicting hepatocellular carcinoma (HCC) recurrence in the present study. Methods: The correlation between serum IgG4:IgG ratio and recurrence was analyzed in a cohort of 195 patients undergoing curative resection in 2012. Another 100 patients were analyzed in a prospective independent cohort during 2012-2013 to validate the value of serum IgG4. Serum IgG4 and total IgG concentrations were measured with an automatic immune analyzer and the optimal cutoff value for serum IgG4 levels was determined by X-tile software. Results: Our data revealed that serum IgG4:IgG were significantly elevated in patients with tumor recurrence (P<0.05). A cutoff IgG:IgG4 ratio of 0.08 was set to stratify HCC patients into high (>0.08) and low (≤0.08) groups. High serum IgG4:IgG ratio correlated with significantly shorter time-to-recurrence (median 11.85 months vs. 39.20, P=0.005). Univariate and multivariate analyses demonstrated that serum IgG4:IgG ratio is an independent indicator of tumor recurrence and this retained its clinical significance even in conventional low-recurrence-risk subgroups, including patients with low α-fetoprotein and early-stage diseases. Conclusion: Our results demonstrated that elevated serum IgG4:IgG ratio is associated with poor clinical outcomes in HCC patients and therefore, and can serve as a novel prognostic predictor for HCC patients undergoing resection. Analyzing serum IgG4 would be useful to tailor individualized therapies for patients. Ivyspring International Publisher 2017-05-12 /pmc/articles/PMC5479238/ /pubmed/28638447 http://dx.doi.org/10.7150/jca.18030 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wu, Jiong
Ma, Xiao-Lu
Tian, Lu
Zhang, Chun-Yan
Wang, Bei-Li
Hu, Yu-Yi
Gao, Xing-Hui
Zhou, Yan
Shen, Min-Na
Peng, Yin-Fei
Pan, Bai-Shen
Zhou, Jian
Fan, Jia
Yang, Xin-Rong
Guo, Wei
Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection
title Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection
title_full Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection
title_fullStr Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection
title_full_unstemmed Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection
title_short Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection
title_sort serum igg4:igg ratio predicts recurrence of patients with hepatocellular carcinoma after curative resection
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479238/
https://www.ncbi.nlm.nih.gov/pubmed/28638447
http://dx.doi.org/10.7150/jca.18030
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