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Controlled release of optimized electroporation enhances the transdermal efficiency of sinomenine hydrochloride for treating arthritis in vitro and in clinic

Sinomenine hydrochloride (SH) is an ideal drug for the treatment of rheumatoid arthritis and osteoarthritis. However, high plasma concentration of systemically administered SH can release histamine, which can cause rash and gastrointestinal side effects. Topical delivery can increase SH concentratio...

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Detalles Bibliográficos
Autores principales:	Feng, Shun, Zhu, Lijun, Huang, Zhisheng, Wang, Haojia, Li, Hong, Zhou, Hua, Lu, Linlin, Wang, Ying, Liu, Zhongqiu, Liu, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479295/ https://www.ncbi.nlm.nih.gov/pubmed/28670109 http://dx.doi.org/10.2147/DDDT.S136313

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