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YC-1 induces G(0)/G(1) phase arrest and mitochondria-dependent apoptosis in cisplatin-resistant human oral cancer CAR cells

Oral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic agent for oral cancer therapy. However, the development of drug resistance and severe side effects cause tremendous problems clinically. In this study, we investigated the pharmacologic mechanisms of YC-1 on...

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Detalles Bibliográficos
Autores principales: Lee, Miau-Rong, Lin, Chingju, Lu, Chi-Cheng, Kuo, Sheng-Chu, Tsao, Je-Wei, Juan, Yu-Ning, Chiu, Hong-Yi, Lee, Fang-Yu, Yang, Jai-Sing, Tsai, Fuu-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: EDP Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479426/
https://www.ncbi.nlm.nih.gov/pubmed/28612710
http://dx.doi.org/10.1051/bmdcn/2017070205