Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression

We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear Y...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yanghua, Gersten, Adam, Moleirinho, Susana, Gunn-Moore, Frank J., Reynolds, Paul A., Prystowsky, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479460/
https://www.ncbi.nlm.nih.gov/pubmed/28725753
http://dx.doi.org/10.1177/2374289515616972
_version_ 1783245132659687424
author Wang, Yanghua
Gersten, Adam
Moleirinho, Susana
Gunn-Moore, Frank J.
Reynolds, Paul A.
Prystowsky, Michael B.
author_facet Wang, Yanghua
Gersten, Adam
Moleirinho, Susana
Gunn-Moore, Frank J.
Reynolds, Paul A.
Prystowsky, Michael B.
author_sort Wang, Yanghua
collection PubMed
description We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.
format Online
Article
Text
id pubmed-5479460
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-54794602017-07-06 Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression Wang, Yanghua Gersten, Adam Moleirinho, Susana Gunn-Moore, Frank J. Reynolds, Paul A. Prystowsky, Michael B. Acad Pathol Article We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion. SAGE Publications 2015-11-26 /pmc/articles/PMC5479460/ /pubmed/28725753 http://dx.doi.org/10.1177/2374289515616972 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
Wang, Yanghua
Gersten, Adam
Moleirinho, Susana
Gunn-Moore, Frank J.
Reynolds, Paul A.
Prystowsky, Michael B.
Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression
title Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression
title_full Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression
title_fullStr Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression
title_full_unstemmed Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression
title_short Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression
title_sort fibroblasts in head and neck squamous cell carcinoma associated with perineural invasion have high-level nuclear yes-associated protein (yap) expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479460/
https://www.ncbi.nlm.nih.gov/pubmed/28725753
http://dx.doi.org/10.1177/2374289515616972
work_keys_str_mv AT wangyanghua fibroblastsinheadandnecksquamouscellcarcinomaassociatedwithperineuralinvasionhavehighlevelnuclearyesassociatedproteinyapexpression
AT gerstenadam fibroblastsinheadandnecksquamouscellcarcinomaassociatedwithperineuralinvasionhavehighlevelnuclearyesassociatedproteinyapexpression
AT moleirinhosusana fibroblastsinheadandnecksquamouscellcarcinomaassociatedwithperineuralinvasionhavehighlevelnuclearyesassociatedproteinyapexpression
AT gunnmoorefrankj fibroblastsinheadandnecksquamouscellcarcinomaassociatedwithperineuralinvasionhavehighlevelnuclearyesassociatedproteinyapexpression
AT reynoldspaula fibroblastsinheadandnecksquamouscellcarcinomaassociatedwithperineuralinvasionhavehighlevelnuclearyesassociatedproteinyapexpression
AT prystowskymichaelb fibroblastsinheadandnecksquamouscellcarcinomaassociatedwithperineuralinvasionhavehighlevelnuclearyesassociatedproteinyapexpression

Ejemplares similares