Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

Myelin is required for proper nervous system function. Schwann cells in developing nerves depend on extrinsic signals from the axon and from the extracellular matrix to first sort and ensheathe a single axon and then myelinate it. Neuregulin 1 type III (Nrg1III) and laminin α2β1γ1 (Lm211) are the ke...

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Detalles Bibliográficos
Autores principales: Ghidinelli, Monica, Poitelon, Yannick, Shin, Yoon Kyoung, Ameroso, Dominique, Williamson, Courtney, Ferri, Cinzia, Pellegatta, Marta, Espino, Kevin, Mogha, Amit, Monk, Kelly, Podini, Paola, Taveggia, Carla, Nave, Klaus-Armin, Wrabetz, Lawrence, Park, Hwan Tae, Feltri, Maria Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479503/
https://www.ncbi.nlm.nih.gov/pubmed/28636612
http://dx.doi.org/10.1371/journal.pbio.2001408

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