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Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals
To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as suggested by recent in vitro studies, independently of confounders. 261 nondiabetic subjects were stratified into tertiles according to kisspeptin values. Insulin secretion was assessed using indexes derived fr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479576/ https://www.ncbi.nlm.nih.gov/pubmed/28636637 http://dx.doi.org/10.1371/journal.pone.0179834 |
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author | Andreozzi, Francesco Mannino, Gaia Chiara Mancuso, Elettra Spiga, Rosangela Perticone, Francesco Sesti, Giorgio |
author_facet | Andreozzi, Francesco Mannino, Gaia Chiara Mancuso, Elettra Spiga, Rosangela Perticone, Francesco Sesti, Giorgio |
author_sort | Andreozzi, Francesco |
collection | PubMed |
description | To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as suggested by recent in vitro studies, independently of confounders. 261 nondiabetic subjects were stratified into tertiles according to kisspeptin values. Insulin secretion was assessed using indexes derived from oral glucose tolerance test (OGTT). After adjusting for age, gender, and BMI, subjects in the highest (tertile 3) kisspeptin group exhibited significantly lower values of insulinogenic index, corrected insulin response (CIR(30)), and Stumvoll indexes for first-phase and second-phase insulin release as compared with low (tertile 1) or intermediate (tertile 2) kisspeptin groups. Univariate correlations between kisspeptin concentration and metabolic variables showed that kisspeptin concentration was significantly and positively correlated with age, blood pressure, and 2-h post-load glucose, and inversely correlated with BMI, and waist circumference. There was an inverse relationship between kisspeptin levels and OGTT-derived indexes of glucose-stimulated insulin secretion. A multivariable regression analysis in a model including all the variables significantly correlated with kisspeptin concentration showed thar age (β = -0.338, P<0.0001), BMI (β = 0.272, P<0.0001), 2-h post-load glucose (β = -0.229, P<0.0001), and kisspeptin (β = -0.105, P = 0.03) remained associated with insulinogenic index. These factors explained 34.6% of the variance of the insulinogenic index. In conclusion, kisspeptin concentrations are associated with insulin secretion independently of important determinants of glucose homeostasis such as gender, age, adiposity, 2-h post-load glucose, and insulin sensitivity. |
format | Online Article Text |
id | pubmed-5479576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54795762017-07-05 Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals Andreozzi, Francesco Mannino, Gaia Chiara Mancuso, Elettra Spiga, Rosangela Perticone, Francesco Sesti, Giorgio PLoS One Research Article To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as suggested by recent in vitro studies, independently of confounders. 261 nondiabetic subjects were stratified into tertiles according to kisspeptin values. Insulin secretion was assessed using indexes derived from oral glucose tolerance test (OGTT). After adjusting for age, gender, and BMI, subjects in the highest (tertile 3) kisspeptin group exhibited significantly lower values of insulinogenic index, corrected insulin response (CIR(30)), and Stumvoll indexes for first-phase and second-phase insulin release as compared with low (tertile 1) or intermediate (tertile 2) kisspeptin groups. Univariate correlations between kisspeptin concentration and metabolic variables showed that kisspeptin concentration was significantly and positively correlated with age, blood pressure, and 2-h post-load glucose, and inversely correlated with BMI, and waist circumference. There was an inverse relationship between kisspeptin levels and OGTT-derived indexes of glucose-stimulated insulin secretion. A multivariable regression analysis in a model including all the variables significantly correlated with kisspeptin concentration showed thar age (β = -0.338, P<0.0001), BMI (β = 0.272, P<0.0001), 2-h post-load glucose (β = -0.229, P<0.0001), and kisspeptin (β = -0.105, P = 0.03) remained associated with insulinogenic index. These factors explained 34.6% of the variance of the insulinogenic index. In conclusion, kisspeptin concentrations are associated with insulin secretion independently of important determinants of glucose homeostasis such as gender, age, adiposity, 2-h post-load glucose, and insulin sensitivity. Public Library of Science 2017-06-21 /pmc/articles/PMC5479576/ /pubmed/28636637 http://dx.doi.org/10.1371/journal.pone.0179834 Text en © 2017 Andreozzi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Andreozzi, Francesco Mannino, Gaia Chiara Mancuso, Elettra Spiga, Rosangela Perticone, Francesco Sesti, Giorgio Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals |
title | Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals |
title_full | Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals |
title_fullStr | Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals |
title_full_unstemmed | Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals |
title_short | Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals |
title_sort | plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479576/ https://www.ncbi.nlm.nih.gov/pubmed/28636637 http://dx.doi.org/10.1371/journal.pone.0179834 |
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