WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely appreciated that the WNT pathway is frequently dysregulated in human cancers through a variety of genetic and epigenetic mechanisms. Targets in the WNT pathway are being exte...

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Detalles Bibliográficos
Autores principales: Fischer, Marcus M., Cancilla, Belinda, Yeung, V. Pete, Cattaruzza, Fiore, Chartier, Cecile, Murriel, Christopher L., Cain, Jennifer, Tam, Raymond, Cheng, Chieh-Yang, Evans, James W., O’Young, Gilbert, Song, Xiaomei, Lewicki, John, Kapoun, Ann M., Gurney, Austin, Yen, Wan-Ching, Hoey, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479655/
https://www.ncbi.nlm.nih.gov/pubmed/28691093
http://dx.doi.org/10.1126/sciadv.1700090

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