Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration

Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infecti...

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Autores principales: Campbell, Andrew, Hogestyn, Jessica M., Folts, Christopher J., Lopez, Brittany, Pröschel, Christoph, Mock, David, Mayer-Pröschel, Margot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479784/
https://www.ncbi.nlm.nih.gov/pubmed/28638124
http://dx.doi.org/10.1038/s41598-017-04432-y
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author Campbell, Andrew
Hogestyn, Jessica M.
Folts, Christopher J.
Lopez, Brittany
Pröschel, Christoph
Mock, David
Mayer-Pröschel, Margot
author_facet Campbell, Andrew
Hogestyn, Jessica M.
Folts, Christopher J.
Lopez, Brittany
Pröschel, Christoph
Mock, David
Mayer-Pröschel, Margot
author_sort Campbell, Andrew
collection PubMed
description Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may contribute to inadequate myelin repair after injury.
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spelling pubmed-54797842017-06-23 Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration Campbell, Andrew Hogestyn, Jessica M. Folts, Christopher J. Lopez, Brittany Pröschel, Christoph Mock, David Mayer-Pröschel, Margot Sci Rep Article Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may contribute to inadequate myelin repair after injury. Nature Publishing Group UK 2017-06-21 /pmc/articles/PMC5479784/ /pubmed/28638124 http://dx.doi.org/10.1038/s41598-017-04432-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Campbell, Andrew
Hogestyn, Jessica M.
Folts, Christopher J.
Lopez, Brittany
Pröschel, Christoph
Mock, David
Mayer-Pröschel, Margot
Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_full Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_fullStr Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_full_unstemmed Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_short Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
title_sort expression of the human herpesvirus 6a latency-associated transcript u94a disrupts human oligodendrocyte progenitor migration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479784/
https://www.ncbi.nlm.nih.gov/pubmed/28638124
http://dx.doi.org/10.1038/s41598-017-04432-y
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