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Immunomodulatory Effects of Nanoparticles on Skin Allergy
In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety of NPs tha...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479793/ https://www.ncbi.nlm.nih.gov/pubmed/28638049 http://dx.doi.org/10.1038/s41598-017-03729-2 |
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author | Jatana, Samreen Palmer, Brian C. Phelan, Sarah J. DeLouise, Lisa A. |
author_facet | Jatana, Samreen Palmer, Brian C. Phelan, Sarah J. DeLouise, Lisa A. |
author_sort | Jatana, Samreen |
collection | PubMed |
description | In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety of NPs that vary in size, charge and composition. Results show that small (<200 nm) negative and neutral charged NPs exhibit an immunosuppressive effect but that positively charged NPs do not. Confocal imaging suggests positively charged NPs may penetrate skin to a lesser extent and thereby are less able interact with and alter the local immune responses. Interestingly, negatively charged silica (20 nm) NPs suppress allergic response to two chemically distinct sensitizers; 1-fluoro-2, 4-dinitrobenzene and 2-deoxyurushiol. Skin wiping and NP application time studies suggest that the immunomodulatory mechanism is not due solely to the blocking of sensitizer adduct formation in skin. Results suggest that NPs modulate early immune events that impact mast cell degranulation. Our study shows for the first time the potential to modulate the elicitation phase of the allergic response which depends on the NP charge and composition. These finding can be used to inform the design topical therapeutics to mitigate allergic responses in skin. |
format | Online Article Text |
id | pubmed-5479793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54797932017-06-23 Immunomodulatory Effects of Nanoparticles on Skin Allergy Jatana, Samreen Palmer, Brian C. Phelan, Sarah J. DeLouise, Lisa A. Sci Rep Article In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety of NPs that vary in size, charge and composition. Results show that small (<200 nm) negative and neutral charged NPs exhibit an immunosuppressive effect but that positively charged NPs do not. Confocal imaging suggests positively charged NPs may penetrate skin to a lesser extent and thereby are less able interact with and alter the local immune responses. Interestingly, negatively charged silica (20 nm) NPs suppress allergic response to two chemically distinct sensitizers; 1-fluoro-2, 4-dinitrobenzene and 2-deoxyurushiol. Skin wiping and NP application time studies suggest that the immunomodulatory mechanism is not due solely to the blocking of sensitizer adduct formation in skin. Results suggest that NPs modulate early immune events that impact mast cell degranulation. Our study shows for the first time the potential to modulate the elicitation phase of the allergic response which depends on the NP charge and composition. These finding can be used to inform the design topical therapeutics to mitigate allergic responses in skin. Nature Publishing Group UK 2017-06-21 /pmc/articles/PMC5479793/ /pubmed/28638049 http://dx.doi.org/10.1038/s41598-017-03729-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jatana, Samreen Palmer, Brian C. Phelan, Sarah J. DeLouise, Lisa A. Immunomodulatory Effects of Nanoparticles on Skin Allergy |
title | Immunomodulatory Effects of Nanoparticles on Skin Allergy |
title_full | Immunomodulatory Effects of Nanoparticles on Skin Allergy |
title_fullStr | Immunomodulatory Effects of Nanoparticles on Skin Allergy |
title_full_unstemmed | Immunomodulatory Effects of Nanoparticles on Skin Allergy |
title_short | Immunomodulatory Effects of Nanoparticles on Skin Allergy |
title_sort | immunomodulatory effects of nanoparticles on skin allergy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479793/ https://www.ncbi.nlm.nih.gov/pubmed/28638049 http://dx.doi.org/10.1038/s41598-017-03729-2 |
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