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The structure-function relationship of disulfide bonds in etanercept

Etanercept is a TNFα receptor Fc fusion protein used for the treatment of rheumatic disease and psoriasis. Physicochemical and functional investigation of process fractions during development of the etanercept biosimilar GP2015 (Erelzi(®)) revealed a correlation between reduced potency and incorrect...

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Detalles Bibliográficos
Autores principales:	Lamanna, William C., Mayer, Robert Ernst, Rupprechter, Alfred, Fuchs, Michael, Higel, Fabian, Fritsch, Cornelius, Vogelsang, Cornelia, Seidl, Andreas, Toll, Hansjoerg, Schiestl, Martin, Holzmann, Johann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479810/ https://www.ncbi.nlm.nih.gov/pubmed/28638112 http://dx.doi.org/10.1038/s41598-017-04320-5

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