Semi-rational engineering of a thermostable aldo–keto reductase from Thermotoga maritima for synthesis of enantiopure ethyl-2-hydroxy-4-phenylbutyrate (EHPB)

A novel aldo-keto reductase Tm1743 characterized from Thermotoga maritima was explored as an effective biocatalyst in chiral alcohol production. Natural Tm1743 catalyzes asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate (EOPB) at high efficiency, but the production of, ethyl (S)-2-hydroxy-4-pheny...

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Detalles Bibliográficos
Autores principales: Wang, Zhiguo, Zhou, Shuo, Zhang, Shuangling, Zhang, Sa, Zhu, Fangmeng, Jin, Xiaolu, Chen, Zhenming, Xu, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479831/
https://www.ncbi.nlm.nih.gov/pubmed/28638047
http://dx.doi.org/10.1038/s41598-017-03947-8

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