Cargando…
What Else Can CD39 Tell Us?
As the rate-limiting enzyme in ATP/ADP–AMP–adenosine pathway, CD39 would be a novel checkpoint inhibitor target in preventing adenosine-triggered immune-suppressive effect. In addition, CD39(hi) Tregs, but not CD25(hi) Tregs, exhibit sustained Foxp3 levels and functional abilities, indicating it cou...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479880/ https://www.ncbi.nlm.nih.gov/pubmed/28690614 http://dx.doi.org/10.3389/fimmu.2017.00727 |
_version_ | 1783245184338755584 |
---|---|
author | Zhao, Hai Bo, Cong Kang, Yan Li, Hong |
author_facet | Zhao, Hai Bo, Cong Kang, Yan Li, Hong |
author_sort | Zhao, Hai |
collection | PubMed |
description | As the rate-limiting enzyme in ATP/ADP–AMP–adenosine pathway, CD39 would be a novel checkpoint inhibitor target in preventing adenosine-triggered immune-suppressive effect. In addition, CD39(hi) Tregs, but not CD25(hi) Tregs, exhibit sustained Foxp3 levels and functional abilities, indicating it could represent a new specific marker of Tregs. Similarly, inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity. Far from conclusive, present research revealed that CD39 also dephosphorylated and thus inactivated self- and pathogen-associated phosphoantigens of Vγ9Vδ2 T cells, which may be the most promising subpopulation for cellular vaccine. CD39 is also tightly related to Th17 cells and can be regarded as a Th17 cells marker. In this review, we focus on present research of CD39 ectoenzyme and provide insights into its clinical application. |
format | Online Article Text |
id | pubmed-5479880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54798802017-07-07 What Else Can CD39 Tell Us? Zhao, Hai Bo, Cong Kang, Yan Li, Hong Front Immunol Immunology As the rate-limiting enzyme in ATP/ADP–AMP–adenosine pathway, CD39 would be a novel checkpoint inhibitor target in preventing adenosine-triggered immune-suppressive effect. In addition, CD39(hi) Tregs, but not CD25(hi) Tregs, exhibit sustained Foxp3 levels and functional abilities, indicating it could represent a new specific marker of Tregs. Similarly, inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity. Far from conclusive, present research revealed that CD39 also dephosphorylated and thus inactivated self- and pathogen-associated phosphoantigens of Vγ9Vδ2 T cells, which may be the most promising subpopulation for cellular vaccine. CD39 is also tightly related to Th17 cells and can be regarded as a Th17 cells marker. In this review, we focus on present research of CD39 ectoenzyme and provide insights into its clinical application. Frontiers Media S.A. 2017-06-22 /pmc/articles/PMC5479880/ /pubmed/28690614 http://dx.doi.org/10.3389/fimmu.2017.00727 Text en Copyright © 2017 Zhao, Bo, Kang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhao, Hai Bo, Cong Kang, Yan Li, Hong What Else Can CD39 Tell Us? |
title | What Else Can CD39 Tell Us? |
title_full | What Else Can CD39 Tell Us? |
title_fullStr | What Else Can CD39 Tell Us? |
title_full_unstemmed | What Else Can CD39 Tell Us? |
title_short | What Else Can CD39 Tell Us? |
title_sort | what else can cd39 tell us? |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479880/ https://www.ncbi.nlm.nih.gov/pubmed/28690614 http://dx.doi.org/10.3389/fimmu.2017.00727 |
work_keys_str_mv | AT zhaohai whatelsecancd39tellus AT bocong whatelsecancd39tellus AT kangyan whatelsecancd39tellus AT lihong whatelsecancd39tellus |