Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations

Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present an overview of the relevant computational stu...

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Detalles Bibliográficos
Autores principales: Vandersickel, Nele, Van Nieuwenhuyse, Enid, Seemann, Gunnar, Panfilov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479889/
https://www.ncbi.nlm.nih.gov/pubmed/28690545
http://dx.doi.org/10.3389/fphys.2017.00404
Descripción
Sumario:Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present an overview of the relevant computational studies on spatial EAD dynamics in 1D, 2D, and in 3D anatomical models and discuss the relation of EADs to cardiac arrhythmias. We also discuss unsolved problems and highlight new lines of research in this area.

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