Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations

Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present an overview of the relevant computational stu...

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Autores principales: Vandersickel, Nele, Van Nieuwenhuyse, Enid, Seemann, Gunnar, Panfilov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479889/
https://www.ncbi.nlm.nih.gov/pubmed/28690545
http://dx.doi.org/10.3389/fphys.2017.00404
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author Vandersickel, Nele
Van Nieuwenhuyse, Enid
Seemann, Gunnar
Panfilov, Alexander V.
author_facet Vandersickel, Nele
Van Nieuwenhuyse, Enid
Seemann, Gunnar
Panfilov, Alexander V.
author_sort Vandersickel, Nele
collection PubMed
description Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present an overview of the relevant computational studies on spatial EAD dynamics in 1D, 2D, and in 3D anatomical models and discuss the relation of EADs to cardiac arrhythmias. We also discuss unsolved problems and highlight new lines of research in this area.
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spelling pubmed-54798892017-07-07 Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations Vandersickel, Nele Van Nieuwenhuyse, Enid Seemann, Gunnar Panfilov, Alexander V. Front Physiol Physiology Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present an overview of the relevant computational studies on spatial EAD dynamics in 1D, 2D, and in 3D anatomical models and discuss the relation of EADs to cardiac arrhythmias. We also discuss unsolved problems and highlight new lines of research in this area. Frontiers Media S.A. 2017-06-22 /pmc/articles/PMC5479889/ /pubmed/28690545 http://dx.doi.org/10.3389/fphys.2017.00404 Text en Copyright © 2017 Vandersickel, Van Nieuwenhuyse, Seemann and Panfilov. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Vandersickel, Nele
Van Nieuwenhuyse, Enid
Seemann, Gunnar
Panfilov, Alexander V.
Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations
title Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations
title_full Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations
title_fullStr Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations
title_full_unstemmed Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations
title_short Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations
title_sort spatial patterns of excitation at tissue and whole organ level due to early afterdepolarizations
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479889/
https://www.ncbi.nlm.nih.gov/pubmed/28690545
http://dx.doi.org/10.3389/fphys.2017.00404
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