Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma

Paraneoplastic syndromes are commonly encountered in renal cell carcinoma, but neurological manifestations are rare. Herein we report a case of a patient with locally advanced renal cell carcinoma who presented with Parkinson-like symptoms which prohibited surgery due to poor performance status. How...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali, Naveed, Kutikov, Alexander, Geynisman, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479944/
https://www.ncbi.nlm.nih.gov/pubmed/28660133
http://dx.doi.org/10.1016/j.eucr.2017.05.007
_version_ 1783245198704246784
author Ali, Naveed
Kutikov, Alexander
Geynisman, Daniel M.
author_facet Ali, Naveed
Kutikov, Alexander
Geynisman, Daniel M.
author_sort Ali, Naveed
collection PubMed
description Paraneoplastic syndromes are commonly encountered in renal cell carcinoma, but neurological manifestations are rare. Herein we report a case of a patient with locally advanced renal cell carcinoma who presented with Parkinson-like symptoms which prohibited surgery due to poor performance status. However, a significant improvement was noted after tyrosine kinase inhibitor therapy, allowing the patient to proceed to curative surgery.
format Online
Article
Text
id pubmed-5479944
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-54799442017-06-28 Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma Ali, Naveed Kutikov, Alexander Geynisman, Daniel M. Urol Case Rep Oncology Paraneoplastic syndromes are commonly encountered in renal cell carcinoma, but neurological manifestations are rare. Herein we report a case of a patient with locally advanced renal cell carcinoma who presented with Parkinson-like symptoms which prohibited surgery due to poor performance status. However, a significant improvement was noted after tyrosine kinase inhibitor therapy, allowing the patient to proceed to curative surgery. Elsevier 2017-06-19 /pmc/articles/PMC5479944/ /pubmed/28660133 http://dx.doi.org/10.1016/j.eucr.2017.05.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Ali, Naveed
Kutikov, Alexander
Geynisman, Daniel M.
Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_full Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_fullStr Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_full_unstemmed Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_short Resolution of a Debilitating Paraneoplastic Parkinson-like Neurological Syndrome Following Tyrosine Inhibitor Therapy and Consolidative Nephrectomy in a Patient with Advanced Clear Cell Renal Cell Carcinoma
title_sort resolution of a debilitating paraneoplastic parkinson-like neurological syndrome following tyrosine inhibitor therapy and consolidative nephrectomy in a patient with advanced clear cell renal cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479944/
https://www.ncbi.nlm.nih.gov/pubmed/28660133
http://dx.doi.org/10.1016/j.eucr.2017.05.007
work_keys_str_mv AT alinaveed resolutionofadebilitatingparaneoplasticparkinsonlikeneurologicalsyndromefollowingtyrosineinhibitortherapyandconsolidativenephrectomyinapatientwithadvancedclearcellrenalcellcarcinoma
AT kutikovalexander resolutionofadebilitatingparaneoplasticparkinsonlikeneurologicalsyndromefollowingtyrosineinhibitortherapyandconsolidativenephrectomyinapatientwithadvancedclearcellrenalcellcarcinoma
AT geynismandanielm resolutionofadebilitatingparaneoplasticparkinsonlikeneurologicalsyndromefollowingtyrosineinhibitortherapyandconsolidativenephrectomyinapatientwithadvancedclearcellrenalcellcarcinoma

Ejemplares similares