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Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)

Current guidelines recommend hepatitis C virus (HCV) testing for HIV-infected men who have sex with men (MSM) with ongoing risk behaviour, without specifying the type of risk behaviour. We developed and validated the HCV-MOSAIC risk score to assist HCV testing in HIV-infected MSM. The risk score con...

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Autores principales: Newsum, Astrid M, Stolte, Ineke G, van der Meer, Jan TM, Schinkel, Janke, van der Valk, Marc, Vanhommerig, Joost W, Buvé, Anne, Danta, Mark, Hogewoning, Arjan, Prins, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479984/
https://www.ncbi.nlm.nih.gov/pubmed/28597832
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.21.30540
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author Newsum, Astrid M
Stolte, Ineke G
van der Meer, Jan TM
Schinkel, Janke
van der Valk, Marc
Vanhommerig, Joost W
Buvé, Anne
Danta, Mark
Hogewoning, Arjan
Prins, Maria
author_facet Newsum, Astrid M
Stolte, Ineke G
van der Meer, Jan TM
Schinkel, Janke
van der Valk, Marc
Vanhommerig, Joost W
Buvé, Anne
Danta, Mark
Hogewoning, Arjan
Prins, Maria
author_sort Newsum, Astrid M
collection PubMed
description Current guidelines recommend hepatitis C virus (HCV) testing for HIV-infected men who have sex with men (MSM) with ongoing risk behaviour, without specifying the type of risk behaviour. We developed and validated the HCV-MOSAIC risk score to assist HCV testing in HIV-infected MSM. The risk score consisted of six self-reported risk factors identified using multivariable logistic regression using data from the Dutch MOSAIC study (n = 213, 2009–2013). Area under the ROC curve (AUC), sensitivity, specificity, post-test-probability-of-disease and diagnostic gain were calculated. The risk score was validated in case–control studies from Belgium (n = 142, 2010–2013) and the United Kingdom (n = 190, 2003–2005) and in cross-sectional surveys at a Dutch sexually transmitted infections clinic (n = 284, 2007–2009). The AUC was 0.82; sensitivity 78.0% and specificity 78.6%. In the validation studies sensitivity ranged from 73.1% to 100% and specificity from 56.2% to 65.6%. The post-test-probability-of-disease ranged from 5.9% to 20.0% given acute HCV prevalence of 1.7% to 6.4%, yielding a diagnostic gain of 4.2% to 13.6%. The HCV-MOSAIC risk score can successfully identify HIV-infected MSM at risk for acute HCV infection. It could be a promising tool to improve HCV testing strategies in various settings.
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spelling pubmed-54799842017-07-07 Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM) Newsum, Astrid M Stolte, Ineke G van der Meer, Jan TM Schinkel, Janke van der Valk, Marc Vanhommerig, Joost W Buvé, Anne Danta, Mark Hogewoning, Arjan Prins, Maria Euro Surveill Research Article Current guidelines recommend hepatitis C virus (HCV) testing for HIV-infected men who have sex with men (MSM) with ongoing risk behaviour, without specifying the type of risk behaviour. We developed and validated the HCV-MOSAIC risk score to assist HCV testing in HIV-infected MSM. The risk score consisted of six self-reported risk factors identified using multivariable logistic regression using data from the Dutch MOSAIC study (n = 213, 2009–2013). Area under the ROC curve (AUC), sensitivity, specificity, post-test-probability-of-disease and diagnostic gain were calculated. The risk score was validated in case–control studies from Belgium (n = 142, 2010–2013) and the United Kingdom (n = 190, 2003–2005) and in cross-sectional surveys at a Dutch sexually transmitted infections clinic (n = 284, 2007–2009). The AUC was 0.82; sensitivity 78.0% and specificity 78.6%. In the validation studies sensitivity ranged from 73.1% to 100% and specificity from 56.2% to 65.6%. The post-test-probability-of-disease ranged from 5.9% to 20.0% given acute HCV prevalence of 1.7% to 6.4%, yielding a diagnostic gain of 4.2% to 13.6%. The HCV-MOSAIC risk score can successfully identify HIV-infected MSM at risk for acute HCV infection. It could be a promising tool to improve HCV testing strategies in various settings. European Centre for Disease Prevention and Control (ECDC) 2017-05-25 /pmc/articles/PMC5479984/ /pubmed/28597832 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.21.30540 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Newsum, Astrid M
Stolte, Ineke G
van der Meer, Jan TM
Schinkel, Janke
van der Valk, Marc
Vanhommerig, Joost W
Buvé, Anne
Danta, Mark
Hogewoning, Arjan
Prins, Maria
Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)
title Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)
title_full Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)
title_fullStr Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)
title_full_unstemmed Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)
title_short Development and validation of the HCV-MOSAIC risk score to assist testing for acute hepatitis C virus (HCV) infection in HIV-infected men who have sex with men (MSM)
title_sort development and validation of the hcv-mosaic risk score to assist testing for acute hepatitis c virus (hcv) infection in hiv-infected men who have sex with men (msm)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479984/
https://www.ncbi.nlm.nih.gov/pubmed/28597832
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.21.30540
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