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A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016

In the Valencian Community (Spain), the programme of maternal pertussis vaccination during pregnancy started in January 2015. The objective of this study was to estimate in this region the vaccine effectiveness (VE) in protecting newborns against laboratory-confirmed pertussis infection. A matched c...

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Autores principales: Bellido-Blasco, Juan, Guiral-Rodrigo, Silvia, Míguez-Santiyán, Ana, Salazar-Cifre, Antonio, González-Morán, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479988/
https://www.ncbi.nlm.nih.gov/pubmed/28598324
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.22.30545
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author Bellido-Blasco, Juan
Guiral-Rodrigo, Silvia
Míguez-Santiyán, Ana
Salazar-Cifre, Antonio
González-Morán, Francisco
author_facet Bellido-Blasco, Juan
Guiral-Rodrigo, Silvia
Míguez-Santiyán, Ana
Salazar-Cifre, Antonio
González-Morán, Francisco
author_sort Bellido-Blasco, Juan
collection PubMed
description In the Valencian Community (Spain), the programme of maternal pertussis vaccination during pregnancy started in January 2015. The objective of this study was to estimate in this region the vaccine effectiveness (VE) in protecting newborns against laboratory-confirmed pertussis infection. A matched case–control study was undertaken in the period between 1 March 2015 and 29 February 2016. Twenty-two cases and 66 controls (+/− 15 days of age difference) were included in the study. Cases were non-vaccinated infants < 3 months of age at disease onset testing positive for pertussis by real-time PCR. For every case three unvaccinated controls were selected. Odds ratios (OR) were calculated by multiple conditional logistic regression for association between maternal vaccination and infant pertussis. Other children in the household, as well as mother- and environmental covariates were taken into account. The VE was calculated as 1 − OR. Mothers of five cases (23%) and of 41 controls (62%) were vaccinated during pregnancy. The adjusted VE was 90.9% (95% confidence interval (CI): 56.6 to 98.1). The only covariate in the final model was breastfeeding (protective effect). Our study provides evidence in favour of pertussis vaccination programmes for pregnant women in order to prevent whooping cough in infants aged less than 3 months.
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spelling pubmed-54799882017-07-07 A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016 Bellido-Blasco, Juan Guiral-Rodrigo, Silvia Míguez-Santiyán, Ana Salazar-Cifre, Antonio González-Morán, Francisco Euro Surveill Research Article In the Valencian Community (Spain), the programme of maternal pertussis vaccination during pregnancy started in January 2015. The objective of this study was to estimate in this region the vaccine effectiveness (VE) in protecting newborns against laboratory-confirmed pertussis infection. A matched case–control study was undertaken in the period between 1 March 2015 and 29 February 2016. Twenty-two cases and 66 controls (+/− 15 days of age difference) were included in the study. Cases were non-vaccinated infants < 3 months of age at disease onset testing positive for pertussis by real-time PCR. For every case three unvaccinated controls were selected. Odds ratios (OR) were calculated by multiple conditional logistic regression for association between maternal vaccination and infant pertussis. Other children in the household, as well as mother- and environmental covariates were taken into account. The VE was calculated as 1 − OR. Mothers of five cases (23%) and of 41 controls (62%) were vaccinated during pregnancy. The adjusted VE was 90.9% (95% confidence interval (CI): 56.6 to 98.1). The only covariate in the final model was breastfeeding (protective effect). Our study provides evidence in favour of pertussis vaccination programmes for pregnant women in order to prevent whooping cough in infants aged less than 3 months. European Centre for Disease Prevention and Control (ECDC) 2017-06-01 /pmc/articles/PMC5479988/ /pubmed/28598324 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.22.30545 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Bellido-Blasco, Juan
Guiral-Rodrigo, Silvia
Míguez-Santiyán, Ana
Salazar-Cifre, Antonio
González-Morán, Francisco
A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016
title A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016
title_full A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016
title_fullStr A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016
title_full_unstemmed A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016
title_short A case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, Valencian community, Spain, 1 March 2015 to 29 February 2016
title_sort case–control study to assess the effectiveness of pertussis vaccination during pregnancy on newborns, valencian community, spain, 1 march 2015 to 29 february 2016
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479988/
https://www.ncbi.nlm.nih.gov/pubmed/28598324
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.22.30545
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