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Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity
AIM: To evaluate the relationship of nonalcoholic fatty liver disease (NAFLD) with nutritional status of vitamin D in extreme obesity. METHODS: Descriptive cross-sectional study in individuals with class III obesity (BMI ≥ 40 kg/m(2)), aged ≥ 20 years to < 60 years. Data were obtained for weight,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480021/ https://www.ncbi.nlm.nih.gov/pubmed/28685131 http://dx.doi.org/10.1155/2017/9456897 |
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author | Cordeiro, Adryana Pereira, Silvia Saboya, Carlos José Ramalho, Andrea |
author_facet | Cordeiro, Adryana Pereira, Silvia Saboya, Carlos José Ramalho, Andrea |
author_sort | Cordeiro, Adryana |
collection | PubMed |
description | AIM: To evaluate the relationship of nonalcoholic fatty liver disease (NAFLD) with nutritional status of vitamin D in extreme obesity. METHODS: Descriptive cross-sectional study in individuals with class III obesity (BMI ≥ 40 kg/m(2)), aged ≥ 20 years to < 60 years. Data were obtained for weight, height, waist circumference (WC), and serum 25-hydroxyvitamin D (25(OH)D) levels. Vitamin D analysis was performed by high performance liquid chromatography (HPLC) and the cutoff points used for its classification were < 20 ng/mL for deficiency and 20–29.9 ng/ml for insufficiency. NAFLD gradation was conducted through histological evaluation by liver biopsy. RESULTS: The sample is comprised of 50 individuals (86% female). BMI and average weight were 44.1 ± 3.8 kg/m(2) and 121.4 ± 21.4 kg, respectively. Sample distribution according to serum 25(OH)D levels showed 42% of deficiency and 48% of insufficiency. The diagnosis of NAFLD was confirmed in 100% of the individuals, of which 70% had steatosis and 30% had steatohepatitis. The highest percentage of 25(OH)D insufficiency was seen in individuals with steatosis (66%/n = 21) and steatohepatitis (93%/n = 16). All individuals with steatohepatitis presented VDD (p < 0.01). CONCLUSION: The results of this study showed high prevalence of serum 25(OH)D inadequacy in individuals with class III obesity, which worsens as the stage of liver disease progresses. |
format | Online Article Text |
id | pubmed-5480021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54800212017-07-06 Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity Cordeiro, Adryana Pereira, Silvia Saboya, Carlos José Ramalho, Andrea Can J Gastroenterol Hepatol Research Article AIM: To evaluate the relationship of nonalcoholic fatty liver disease (NAFLD) with nutritional status of vitamin D in extreme obesity. METHODS: Descriptive cross-sectional study in individuals with class III obesity (BMI ≥ 40 kg/m(2)), aged ≥ 20 years to < 60 years. Data were obtained for weight, height, waist circumference (WC), and serum 25-hydroxyvitamin D (25(OH)D) levels. Vitamin D analysis was performed by high performance liquid chromatography (HPLC) and the cutoff points used for its classification were < 20 ng/mL for deficiency and 20–29.9 ng/ml for insufficiency. NAFLD gradation was conducted through histological evaluation by liver biopsy. RESULTS: The sample is comprised of 50 individuals (86% female). BMI and average weight were 44.1 ± 3.8 kg/m(2) and 121.4 ± 21.4 kg, respectively. Sample distribution according to serum 25(OH)D levels showed 42% of deficiency and 48% of insufficiency. The diagnosis of NAFLD was confirmed in 100% of the individuals, of which 70% had steatosis and 30% had steatohepatitis. The highest percentage of 25(OH)D insufficiency was seen in individuals with steatosis (66%/n = 21) and steatohepatitis (93%/n = 16). All individuals with steatohepatitis presented VDD (p < 0.01). CONCLUSION: The results of this study showed high prevalence of serum 25(OH)D inadequacy in individuals with class III obesity, which worsens as the stage of liver disease progresses. Hindawi 2017 2017-06-08 /pmc/articles/PMC5480021/ /pubmed/28685131 http://dx.doi.org/10.1155/2017/9456897 Text en Copyright © 2017 Adryana Cordeiro et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cordeiro, Adryana Pereira, Silvia Saboya, Carlos José Ramalho, Andrea Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity |
title | Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity |
title_full | Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity |
title_fullStr | Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity |
title_full_unstemmed | Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity |
title_short | Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity |
title_sort | relationship between nonalcoholic fatty liver disease and vitamin d nutritional status in extreme obesity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480021/ https://www.ncbi.nlm.nih.gov/pubmed/28685131 http://dx.doi.org/10.1155/2017/9456897 |
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