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Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice
Nonalcoholic fatty liver disease, induced by a Western diet (WD), evokes central and peripheral inflammation that is accompanied by altered emotionality. These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480052/ https://www.ncbi.nlm.nih.gov/pubmed/28685102 http://dx.doi.org/10.1155/2017/9498247 |
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author | Veniaminova, Ekaterina Cespuglio, Raymond Cheung, Chi Wai Umriukhin, Alexei Markova, Nataliia Shevtsova, Elena Lesch, Klaus-Peter Anthony, Daniel C. Strekalova, Tatyana |
author_facet | Veniaminova, Ekaterina Cespuglio, Raymond Cheung, Chi Wai Umriukhin, Alexei Markova, Nataliia Shevtsova, Elena Lesch, Klaus-Peter Anthony, Daniel C. Strekalova, Tatyana |
author_sort | Veniaminova, Ekaterina |
collection | PubMed |
description | Nonalcoholic fatty liver disease, induced by a Western diet (WD), evokes central and peripheral inflammation that is accompanied by altered emotionality. These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J mice were fed with a regular chow or with a WD containing 0.2% of cholesterol and 21% of saturated fat for three weeks. WD-treated mice exhibited increased social avoidance, crawl-over and digging behaviours, decreased body-body contacts, and hyperlocomotion. The WD-fed group also displayed deficits in hippocampal-dependent performance such as contextual memory in a fear conditioning and pellet displacement paradigms. A reduction in glucose tolerance and elevated levels of serum cholesterol and leptin were also associated with the WD. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1a) mRNA, a marker of mitochondrial activity, was decreased in the prefrontal cortex, hippocampus, hypothalamus, and dorsal raphe, suggesting suppressed brain mitochondrial functions, but not in the liver. This is the first report to show that a WD can profoundly suppress social interactions and induce dominant-like behaviours in naïve adult mice. The spectrum of behaviours that were found to be induced are reminiscent of symptoms associated with autism, and, if paralleled in humans, suggest that a WD might exacerbate autism spectrum disorder. |
format | Online Article Text |
id | pubmed-5480052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-54800522017-07-06 Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice Veniaminova, Ekaterina Cespuglio, Raymond Cheung, Chi Wai Umriukhin, Alexei Markova, Nataliia Shevtsova, Elena Lesch, Klaus-Peter Anthony, Daniel C. Strekalova, Tatyana Neural Plast Research Article Nonalcoholic fatty liver disease, induced by a Western diet (WD), evokes central and peripheral inflammation that is accompanied by altered emotionality. These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J mice were fed with a regular chow or with a WD containing 0.2% of cholesterol and 21% of saturated fat for three weeks. WD-treated mice exhibited increased social avoidance, crawl-over and digging behaviours, decreased body-body contacts, and hyperlocomotion. The WD-fed group also displayed deficits in hippocampal-dependent performance such as contextual memory in a fear conditioning and pellet displacement paradigms. A reduction in glucose tolerance and elevated levels of serum cholesterol and leptin were also associated with the WD. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1a) mRNA, a marker of mitochondrial activity, was decreased in the prefrontal cortex, hippocampus, hypothalamus, and dorsal raphe, suggesting suppressed brain mitochondrial functions, but not in the liver. This is the first report to show that a WD can profoundly suppress social interactions and induce dominant-like behaviours in naïve adult mice. The spectrum of behaviours that were found to be induced are reminiscent of symptoms associated with autism, and, if paralleled in humans, suggest that a WD might exacerbate autism spectrum disorder. Hindawi 2017 2017-06-08 /pmc/articles/PMC5480052/ /pubmed/28685102 http://dx.doi.org/10.1155/2017/9498247 Text en Copyright © 2017 Ekaterina Veniaminova et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Veniaminova, Ekaterina Cespuglio, Raymond Cheung, Chi Wai Umriukhin, Alexei Markova, Nataliia Shevtsova, Elena Lesch, Klaus-Peter Anthony, Daniel C. Strekalova, Tatyana Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice |
title | Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice |
title_full | Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice |
title_fullStr | Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice |
title_full_unstemmed | Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice |
title_short | Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice |
title_sort | autism-like behaviours and memory deficits result from a western diet in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480052/ https://www.ncbi.nlm.nih.gov/pubmed/28685102 http://dx.doi.org/10.1155/2017/9498247 |
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