Cargando…

Cancer with low cathepsin D levels is susceptible to vacuolar (H(+))‐ATPase inhibition

Vacuolar (H(+))‐ATPases (V‐ATPases) have important roles in the supply of nutrients to tumors by mediating autophagy and the endocytic uptake of extracellular fluids. Accordingly, V‐ATPases are attractive therapeutic targets for cancer. However, the clinical use of V‐ATPase inhibitors as anticancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kitazawa, Satoshi, Nishizawa, Satoru, Nakagawa, Hideyuki, Funata, Masaaki, Nishimura, Kazuho, Soga, Tomoyoshi, Hara, Takahito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480082/ https://www.ncbi.nlm.nih.gov/pubmed/28317223 http://dx.doi.org/10.1111/cas.13240

Ejemplares similares

Effects of Vacuolar H(+)-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells
por: Uhlman, Andrew, et al.
Publicado: (2017)

Flexibility within the Rotor and Stators of the Vacuolar H(+)-ATPase
por: Song, Chun Feng, et al.
Publicado: (2013)

An isoform of the vacuolar (H(+))-ATPase accessory subunit Ac45
por: Jansen, Eric J. R., et al.
Publicado: (2009)

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
por: Di Cristofori, Andrea, et al.
Publicado: (2015)

Succinate dehydrogenase B-deficient cancer cells are highly sensitive to bromodomain and extra-terminal inhibitors
por: Kitazawa, Satoshi, et al.
Publicado: (2017)

Nicotine Affects Bone Resorption and Suppresses the Expression of Cathepsin K, MMP-9 and Vacuolar-Type H(+)-ATPase d2 and Actin Organization in Osteoclasts
por: Tanaka, Hideki, et al.
Publicado: (2013)

Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H(+))-ATPase Inhibitors †
por: Patil, Renukadevi, et al.
Publicado: (2017)

Vacuolar H(+)-ATPase is not restricted to clear cells of the epididymal epithelium in cattle
por: Kim, Sung Woo, et al.
Publicado: (2021)

Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins
Publicado: (1989)

STAT3 associates with vacuolar H(+)-ATPase and regulates cytosolic and lysosomal pH
por: Liu, Bin, et al.
Publicado: (2018)

Role of the vacuolar ATPase in the Alphavirus replication cycle
por: Schuchman, Ryan M., et al.
Publicado: (2018)

Reconstitution of Vacuolar-type Rotary H(+)-ATPase/Synthase from Thermus thermophilus
por: Kishikawa, Jun-ichi, et al.
Publicado: (2012)

The Vacuolar-Type H(+)-ATPase in Ovine Rumen Epithelium is Regulated by Metabolic Signals
por: Kuzinski, Judith, et al.
Publicado: (2010)

Inhibition of Host Vacuolar H(+)-ATPase Activity by a Legionella pneumophila Effector
por: Xu, Li, et al.
Publicado: (2010)

The d subunit plays a central role in human vacuolar H(+)-ATPases
por: Smith, Annabel N., et al.
Publicado: (2008)

Retrieval of the Vacuolar H(+)-ATPase from Phagosomes Revealed by Live Cell Imaging
por: Clarke, Margaret, et al.
Publicado: (2010)

Structure of the Vacuolar H(+)-ATPase Rotary Motor Reveals New Mechanistic Insights
por: Rawson, Shaun, et al.
Publicado: (2015)

Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling
por: Kobia, Francis, et al.
Publicado: (2013)

Purification of active human vacuolar H(+)-ATPase in native lipid-containing nanodiscs
por: Oot, Rebecca A., et al.
Publicado: (2021)

Acidification of endothelial Weibel-Palade bodies is mediated by the vacuolar-type H(+)-ATPase
por: Terglane, Julian, et al.
Publicado: (2022)

Rotating with the brakes on and other unresolved features of the vacuolar ATPase
por: Rawson, Shaun, et al.
Publicado: (2016)

The curious case of vacuolar ATPase: regulation of signaling pathways
por: Pamarthy, Sahithi, et al.
Publicado: (2018)

Mutations in the Proteolipid Subunits of the Vacuolar H(+)-ATPase Provide Resistance to Indolotryptoline Natural Products
por: Chang, Fang-Yuan, et al.
Publicado: (2014)

A pivotal role of vacuolar H(+)-ATPase in regulation of lipid production in Phaeodactylum tricornutum
por: Zhang, Huiying, et al.
Publicado: (2016)

Detection and quantification of the vacuolar H(+)ATPase using the Legionella effector protein SidK
por: Maxson, Michelle E., et al.
Publicado: (2022)

Adipocytes control food intake and weight regain via Vacuolar-type H(+) ATPase
por: Zapata, Rizaldy C., et al.
Publicado: (2022)

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy
por: Hayek, Summer R., et al.
Publicado: (2014)

The Toxoplasma Vacuolar H(+)-ATPase Regulates Intracellular pH and Impacts the Maturation of Essential Secretory Proteins
por: Stasic, Andrew J., et al.
Publicado: (2019)

Genome-Wide Identification and Characterization of the Vacuolar H(+)-ATPase Subunit H Gene Family in Crop Plants
por: Kang, Chen, et al.
Publicado: (2019)

Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases
por: Mazhab-Jafari, Mohammad T., et al.
Publicado: (2016)

Vacuolar-type ATPase: A proton pump to lysosomal trafficking
por: FUTAI, Masamitsu, et al.
Publicado: (2019)

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii
por: Chang, Ya-Wen, et al.
Publicado: (2021)

Expression of 16 kDa proteolipid of vacuolar-type H(+)-ATPase in human pancreatic cancer.
por: Ohta, T., et al.
Publicado: (1996)

Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts
Publicado: (1990)

Covalent Targeting of the Vacuolar H(+)-ATPase Activates Autophagy Via mTORC1 Inhibition
por: Yik-Sham Chung, Clive, et al.
Publicado: (2019)

Augmenting Vacuolar H(+)-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction
por: Wang, Shujin, et al.
Publicado: (2020)

The vacuolar-ATPase (V-ATPase) modulates matrix metalloproteinase (MMP) isoforms in human pancreatic cancer
por: Chung, Chuhan, et al.
Publicado: (2011)

Cloning, Expression and Purification of Subunit H of Vacuolar H(+)-ATPase from Mythimna separata Walker (Lepidoptera: Noctuidae)
por: Lu, Lina, et al.
Publicado: (2014)

Extracellular and Luminal pH Regulation by Vacuolar H(+)-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes
por: Smith, Gina A., et al.
Publicado: (2016)

Endocytosis is required for the growth of vacuolar H(+)-ATPase- defective yeast: identification of six new END genes
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_lg8mndnlsp9676q25njng3g4ed