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Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer’s disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. The extent to which the data from mice can be transferred to man...

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Detalles Bibliográficos
Autores principales:	Steffen, Johannes, Krohn, Markus, Schwitlick, Christina, Brüning, Thomas, Paarmann, Kristin, Pietrzik, Claus U., Biverstål, Henrik, Jansone, Baiba, Langer, Oliver, Pahnke, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480119/ https://www.ncbi.nlm.nih.gov/pubmed/28637503 http://dx.doi.org/10.1186/s40478-017-0448-2

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