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The efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis
BACKGROUND: There is no consistent conclusion regarding the efficacy and safety of the intravenous administration of tranexamic acid (TXA) for reducing blood loss in revision total knee arthroplasty (TKA). We performed a meta-analysis of comparative trials to evaluate the efficacy and safety of TXA...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480129/ https://www.ncbi.nlm.nih.gov/pubmed/28637438 http://dx.doi.org/10.1186/s12891-017-1633-y |
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author | Tian, Peng Liu, Wen-bin Li, Zhi-jun Xu, Gui-jun Huang, Yu-ting Ma, Xin-long |
author_facet | Tian, Peng Liu, Wen-bin Li, Zhi-jun Xu, Gui-jun Huang, Yu-ting Ma, Xin-long |
author_sort | Tian, Peng |
collection | PubMed |
description | BACKGROUND: There is no consistent conclusion regarding the efficacy and safety of the intravenous administration of tranexamic acid (TXA) for reducing blood loss in revision total knee arthroplasty (TKA). We performed a meta-analysis of comparative trials to evaluate the efficacy and safety of TXA in revision TKA. METHODS: We conducted a search of PubMed, EMBASE, The Cochrane Library and Web of Science for randomized controlled trials (RCTs) and non-RCTs. Two authors selected the studies, extracted the data, and assessed the risk of bias independently. A pooled meta-analysis was performed using RevMan 5.3 software. RESULTS: Four non-RCTs met the inclusion criteria. The meta-analysis indicated that the use of TXA was related to significantly less transfusion requirements (RD = −0.25; 95% CI: -0.43 to −0.08; P = 0.005), drainage volume (MD = −321.07; 95% CI: -445.13 to −197.01, P = 0.005), hemoglobin reduction (MD = −0.52; 95% CI: -0.79 to −0.25, P = 0.0001), and length of hospital stay (MD = −2.36; 95% CI: -4.00 to −0.71, P = 0.005). No significant differences in the incidence of deep venous thrombosis (DVT) or pulmonary embolism (PE) were noted. CONCLUSIONS: The use of TXA for patients undergoing revision TKA may reduce blood loss and transfusion requirements without increasing the risk of postoperative venous thromboembolism. Due to the limited quality of the currently available evidence, more high-quality RCTs are required. |
format | Online Article Text |
id | pubmed-5480129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54801292017-06-23 The efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis Tian, Peng Liu, Wen-bin Li, Zhi-jun Xu, Gui-jun Huang, Yu-ting Ma, Xin-long BMC Musculoskelet Disord Research Article BACKGROUND: There is no consistent conclusion regarding the efficacy and safety of the intravenous administration of tranexamic acid (TXA) for reducing blood loss in revision total knee arthroplasty (TKA). We performed a meta-analysis of comparative trials to evaluate the efficacy and safety of TXA in revision TKA. METHODS: We conducted a search of PubMed, EMBASE, The Cochrane Library and Web of Science for randomized controlled trials (RCTs) and non-RCTs. Two authors selected the studies, extracted the data, and assessed the risk of bias independently. A pooled meta-analysis was performed using RevMan 5.3 software. RESULTS: Four non-RCTs met the inclusion criteria. The meta-analysis indicated that the use of TXA was related to significantly less transfusion requirements (RD = −0.25; 95% CI: -0.43 to −0.08; P = 0.005), drainage volume (MD = −321.07; 95% CI: -445.13 to −197.01, P = 0.005), hemoglobin reduction (MD = −0.52; 95% CI: -0.79 to −0.25, P = 0.0001), and length of hospital stay (MD = −2.36; 95% CI: -4.00 to −0.71, P = 0.005). No significant differences in the incidence of deep venous thrombosis (DVT) or pulmonary embolism (PE) were noted. CONCLUSIONS: The use of TXA for patients undergoing revision TKA may reduce blood loss and transfusion requirements without increasing the risk of postoperative venous thromboembolism. Due to the limited quality of the currently available evidence, more high-quality RCTs are required. BioMed Central 2017-06-21 /pmc/articles/PMC5480129/ /pubmed/28637438 http://dx.doi.org/10.1186/s12891-017-1633-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Tian, Peng Liu, Wen-bin Li, Zhi-jun Xu, Gui-jun Huang, Yu-ting Ma, Xin-long The efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis |
title | The efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis |
title_full | The efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis |
title_fullStr | The efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis |
title_full_unstemmed | The efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis |
title_short | The efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis |
title_sort | efficacy and safety of tranexamic acid in revision total knee arthroplasty: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480129/ https://www.ncbi.nlm.nih.gov/pubmed/28637438 http://dx.doi.org/10.1186/s12891-017-1633-y |
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