HOTAIR: a key regulator in gynecologic cancers

Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoRES...

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Autores principales: Li, Jing, Wang, Jing, Zhong, Yan, Guo, Ruixia, Chu, Danxia, Qiu, Haifeng, Yuan, Zhongfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480152/
https://www.ncbi.nlm.nih.gov/pubmed/28649178
http://dx.doi.org/10.1186/s12935-017-0434-6
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author Li, Jing
Wang, Jing
Zhong, Yan
Guo, Ruixia
Chu, Danxia
Qiu, Haifeng
Yuan, Zhongfu
author_facet Li, Jing
Wang, Jing
Zhong, Yan
Guo, Ruixia
Chu, Danxia
Qiu, Haifeng
Yuan, Zhongfu
author_sort Li, Jing
collection PubMed
description Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes. HOTAIR promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways. HOTAIR is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing HOTAIR function are unknown. In this review, we summarize the recent findings on the roles of HOTAIR in gynecologic cancers.
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spelling pubmed-54801522017-06-23 HOTAIR: a key regulator in gynecologic cancers Li, Jing Wang, Jing Zhong, Yan Guo, Ruixia Chu, Danxia Qiu, Haifeng Yuan, Zhongfu Cancer Cell Int Review Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes. HOTAIR promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways. HOTAIR is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing HOTAIR function are unknown. In this review, we summarize the recent findings on the roles of HOTAIR in gynecologic cancers. BioMed Central 2017-06-21 /pmc/articles/PMC5480152/ /pubmed/28649178 http://dx.doi.org/10.1186/s12935-017-0434-6 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Jing
Wang, Jing
Zhong, Yan
Guo, Ruixia
Chu, Danxia
Qiu, Haifeng
Yuan, Zhongfu
HOTAIR: a key regulator in gynecologic cancers
title HOTAIR: a key regulator in gynecologic cancers
title_full HOTAIR: a key regulator in gynecologic cancers
title_fullStr HOTAIR: a key regulator in gynecologic cancers
title_full_unstemmed HOTAIR: a key regulator in gynecologic cancers
title_short HOTAIR: a key regulator in gynecologic cancers
title_sort hotair: a key regulator in gynecologic cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480152/
https://www.ncbi.nlm.nih.gov/pubmed/28649178
http://dx.doi.org/10.1186/s12935-017-0434-6
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AT chudanxia hotairakeyregulatoringynecologiccancers
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