Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in skeletal muscle. The DUX4 transcription factor has DNA binding domains similar to several paired class homeotic transcription factors...

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Detalles Bibliográficos
Autores principales: Haynes, Premi, Kernan, Kelly, Zhou, Suk-Lin, Miller, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480156/
https://www.ncbi.nlm.nih.gov/pubmed/28637492
http://dx.doi.org/10.1186/s13395-017-0130-1

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