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Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports

BACKGROUND: Granulosa cell tumor of the ovary is the most frequent sex cord stromal tumor and represents 2 to 5% of all primary ovarian cancers. Ovarian granulosa cell tumor is a malignant tumor with slow progression and in some cases this tumor is hormonally active. The recurrence of granulosa cell...

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Autores principales: Bufa, Anita, Farkas, Nelli, Preisz, Zsolt, Poór, Viktória, Páger, Csilla, Szukits, Sándor, Farkas, Bálint, Gőcze, Péter Miklós
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480180/
https://www.ncbi.nlm.nih.gov/pubmed/28637499
http://dx.doi.org/10.1186/s13256-017-1324-1
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author Bufa, Anita
Farkas, Nelli
Preisz, Zsolt
Poór, Viktória
Páger, Csilla
Szukits, Sándor
Farkas, Bálint
Gőcze, Péter Miklós
author_facet Bufa, Anita
Farkas, Nelli
Preisz, Zsolt
Poór, Viktória
Páger, Csilla
Szukits, Sándor
Farkas, Bálint
Gőcze, Péter Miklós
author_sort Bufa, Anita
collection PubMed
description BACKGROUND: Granulosa cell tumor of the ovary is the most frequent sex cord stromal tumor and represents 2 to 5% of all primary ovarian cancers. Ovarian granulosa cell tumor is a malignant tumor with slow progression and in some cases this tumor is hormonally active. The recurrence of granulosa cell tumor often happens after 5 years. CASE PRESENTATION: We describe two cases of postmenopausal women with adult-type granulosa cell tumors of the ovary. Patient 1 is a 49-year-old European woman with a recurrent tumor; patient 2 is a 55-year-old European woman without recurrence of tumor. Urinary steroid profiles of patient 1 were monitored during a 5-year period starting from before an operation (13 samples). In patient 2, the urinary steroid profiles were monitored during a 3-year period starting from after an operation (six samples). The 24-hour urinary samples were examined and the urinary concentration of 20 androgen, progesterone, and corticoid metabolites was quantitatively determined by gas chromatography-mass spectrometry with selected ion-monitoring mode. CONCLUSIONS: Based on these cases a correlation could be observed between increased levels of the urinary steroids and the recurrence of ovarian granulosa cell tumor; therefore, we concluded that a urinary steroid profile could be a more effective method to follow-up such patients compared to the traditional serum hormones determinations supplemented with conventional tumor markers.
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spelling pubmed-54801802017-06-23 Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports Bufa, Anita Farkas, Nelli Preisz, Zsolt Poór, Viktória Páger, Csilla Szukits, Sándor Farkas, Bálint Gőcze, Péter Miklós J Med Case Rep Case Report BACKGROUND: Granulosa cell tumor of the ovary is the most frequent sex cord stromal tumor and represents 2 to 5% of all primary ovarian cancers. Ovarian granulosa cell tumor is a malignant tumor with slow progression and in some cases this tumor is hormonally active. The recurrence of granulosa cell tumor often happens after 5 years. CASE PRESENTATION: We describe two cases of postmenopausal women with adult-type granulosa cell tumors of the ovary. Patient 1 is a 49-year-old European woman with a recurrent tumor; patient 2 is a 55-year-old European woman without recurrence of tumor. Urinary steroid profiles of patient 1 were monitored during a 5-year period starting from before an operation (13 samples). In patient 2, the urinary steroid profiles were monitored during a 3-year period starting from after an operation (six samples). The 24-hour urinary samples were examined and the urinary concentration of 20 androgen, progesterone, and corticoid metabolites was quantitatively determined by gas chromatography-mass spectrometry with selected ion-monitoring mode. CONCLUSIONS: Based on these cases a correlation could be observed between increased levels of the urinary steroids and the recurrence of ovarian granulosa cell tumor; therefore, we concluded that a urinary steroid profile could be a more effective method to follow-up such patients compared to the traditional serum hormones determinations supplemented with conventional tumor markers. BioMed Central 2017-06-22 /pmc/articles/PMC5480180/ /pubmed/28637499 http://dx.doi.org/10.1186/s13256-017-1324-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Bufa, Anita
Farkas, Nelli
Preisz, Zsolt
Poór, Viktória
Páger, Csilla
Szukits, Sándor
Farkas, Bálint
Gőcze, Péter Miklós
Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports
title Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports
title_full Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports
title_fullStr Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports
title_full_unstemmed Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports
title_short Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports
title_sort diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480180/
https://www.ncbi.nlm.nih.gov/pubmed/28637499
http://dx.doi.org/10.1186/s13256-017-1324-1
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