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Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports
BACKGROUND: Granulosa cell tumor of the ovary is the most frequent sex cord stromal tumor and represents 2 to 5% of all primary ovarian cancers. Ovarian granulosa cell tumor is a malignant tumor with slow progression and in some cases this tumor is hormonally active. The recurrence of granulosa cell...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480180/ https://www.ncbi.nlm.nih.gov/pubmed/28637499 http://dx.doi.org/10.1186/s13256-017-1324-1 |
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author | Bufa, Anita Farkas, Nelli Preisz, Zsolt Poór, Viktória Páger, Csilla Szukits, Sándor Farkas, Bálint Gőcze, Péter Miklós |
author_facet | Bufa, Anita Farkas, Nelli Preisz, Zsolt Poór, Viktória Páger, Csilla Szukits, Sándor Farkas, Bálint Gőcze, Péter Miklós |
author_sort | Bufa, Anita |
collection | PubMed |
description | BACKGROUND: Granulosa cell tumor of the ovary is the most frequent sex cord stromal tumor and represents 2 to 5% of all primary ovarian cancers. Ovarian granulosa cell tumor is a malignant tumor with slow progression and in some cases this tumor is hormonally active. The recurrence of granulosa cell tumor often happens after 5 years. CASE PRESENTATION: We describe two cases of postmenopausal women with adult-type granulosa cell tumors of the ovary. Patient 1 is a 49-year-old European woman with a recurrent tumor; patient 2 is a 55-year-old European woman without recurrence of tumor. Urinary steroid profiles of patient 1 were monitored during a 5-year period starting from before an operation (13 samples). In patient 2, the urinary steroid profiles were monitored during a 3-year period starting from after an operation (six samples). The 24-hour urinary samples were examined and the urinary concentration of 20 androgen, progesterone, and corticoid metabolites was quantitatively determined by gas chromatography-mass spectrometry with selected ion-monitoring mode. CONCLUSIONS: Based on these cases a correlation could be observed between increased levels of the urinary steroids and the recurrence of ovarian granulosa cell tumor; therefore, we concluded that a urinary steroid profile could be a more effective method to follow-up such patients compared to the traditional serum hormones determinations supplemented with conventional tumor markers. |
format | Online Article Text |
id | pubmed-5480180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54801802017-06-23 Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports Bufa, Anita Farkas, Nelli Preisz, Zsolt Poór, Viktória Páger, Csilla Szukits, Sándor Farkas, Bálint Gőcze, Péter Miklós J Med Case Rep Case Report BACKGROUND: Granulosa cell tumor of the ovary is the most frequent sex cord stromal tumor and represents 2 to 5% of all primary ovarian cancers. Ovarian granulosa cell tumor is a malignant tumor with slow progression and in some cases this tumor is hormonally active. The recurrence of granulosa cell tumor often happens after 5 years. CASE PRESENTATION: We describe two cases of postmenopausal women with adult-type granulosa cell tumors of the ovary. Patient 1 is a 49-year-old European woman with a recurrent tumor; patient 2 is a 55-year-old European woman without recurrence of tumor. Urinary steroid profiles of patient 1 were monitored during a 5-year period starting from before an operation (13 samples). In patient 2, the urinary steroid profiles were monitored during a 3-year period starting from after an operation (six samples). The 24-hour urinary samples were examined and the urinary concentration of 20 androgen, progesterone, and corticoid metabolites was quantitatively determined by gas chromatography-mass spectrometry with selected ion-monitoring mode. CONCLUSIONS: Based on these cases a correlation could be observed between increased levels of the urinary steroids and the recurrence of ovarian granulosa cell tumor; therefore, we concluded that a urinary steroid profile could be a more effective method to follow-up such patients compared to the traditional serum hormones determinations supplemented with conventional tumor markers. BioMed Central 2017-06-22 /pmc/articles/PMC5480180/ /pubmed/28637499 http://dx.doi.org/10.1186/s13256-017-1324-1 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Bufa, Anita Farkas, Nelli Preisz, Zsolt Poór, Viktória Páger, Csilla Szukits, Sándor Farkas, Bálint Gőcze, Péter Miklós Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports |
title | Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports |
title_full | Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports |
title_fullStr | Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports |
title_full_unstemmed | Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports |
title_short | Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports |
title_sort | diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480180/ https://www.ncbi.nlm.nih.gov/pubmed/28637499 http://dx.doi.org/10.1186/s13256-017-1324-1 |
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