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Eliminating acetate formation improves citramalate production by metabolically engineered Escherichia coli

BACKGROUND: Citramalate, a chemical precursor to the industrially important methacrylic acid (MAA), can be synthesized using Escherichia coli overexpressing citramalate synthase (cimA gene). Deletion of gltA encoding citrate synthase and leuC encoding 3-isopropylmalate dehydratase were critical to a...

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Detalles Bibliográficos
Autores principales:	Parimi, Naga Sirisha, Durie, Ian A., Wu, Xianghao, Niyas, Afaq M. M., Eiteman, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480221/ https://www.ncbi.nlm.nih.gov/pubmed/28637476 http://dx.doi.org/10.1186/s12934-017-0729-2

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