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Pharmacokinetics and Pharmacodynamics of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: Phase 2 Trials for Dose Selection in the Pivotal Phase 3 Trial

In the pivotal TEMPO 3:4 trial, the arginine vasopressin V2‐receptor antagonist tolvaptan reduced the rate of kidney growth in patients with autosomal dominant polycystic kidney disease. Tolvaptan was initiated as daily morning/afternoon doses of 45/15 mg, and uptitrated weekly to 60/30 mg and 90/30...

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Detalles Bibliográficos
Autores principales:	Shoaf, Susan E., Chapman, Arlene B., Torres, Vicente E., Ouyang, John, Czerwiec, Frank S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Pharmacokinetics/Pharmacodynamics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480307/ https://www.ncbi.nlm.nih.gov/pubmed/28218410 http://dx.doi.org/10.1002/jcph.880

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