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Interactions between shape-persistent macromolecules as probed by AFM
Water-soluble shape-persistent cyclodextrin (CD) polymers with amino-functionalized end groups were prepared starting from diacetylene-modified cyclodextrin monomers by a combined Glaser coupling/click chemistry approach. Structural perfection of the neutral CD polymers and inclusion complex formati...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480325/ https://www.ncbi.nlm.nih.gov/pubmed/28684975 http://dx.doi.org/10.3762/bjoc.13.95 |
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author | Blass, Johanna Brunke, Jessica Emmerich, Franziska Przybylski, Cédric Garamus, Vasil M Feoktystov, Artem Bennewitz, Roland Wenz, Gerhard Albrecht, Marcel |
author_facet | Blass, Johanna Brunke, Jessica Emmerich, Franziska Przybylski, Cédric Garamus, Vasil M Feoktystov, Artem Bennewitz, Roland Wenz, Gerhard Albrecht, Marcel |
author_sort | Blass, Johanna |
collection | PubMed |
description | Water-soluble shape-persistent cyclodextrin (CD) polymers with amino-functionalized end groups were prepared starting from diacetylene-modified cyclodextrin monomers by a combined Glaser coupling/click chemistry approach. Structural perfection of the neutral CD polymers and inclusion complex formation with ditopic and monotopic guest molecules were proven by MALDI–TOF and UV–vis measurements. Small-angle neutron and X-ray (SANS/SAXS) scattering experiments confirm the stiffness of the polymer chains with an apparent contour length of about 130 Å. Surface modification of planar silicon wafers as well as AFM tips was realized by covalent bound formation between the terminal amino groups of the CD polymer and a reactive isothiocyanate–silane monolayer. Atomic force measurements of CD polymer decorated surfaces show enhanced supramolecular interaction energies which can be attributed to multiple inclusion complexes based on the rigidity of the polymer backbone and the regular configuration of the CD moieties. Depending on the geometrical configuration of attachment anisotropic adhesion characteristics of the polymer system can be distinguished between a peeling and a shearing mechanism. |
format | Online Article Text |
id | pubmed-5480325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-54803252017-07-06 Interactions between shape-persistent macromolecules as probed by AFM Blass, Johanna Brunke, Jessica Emmerich, Franziska Przybylski, Cédric Garamus, Vasil M Feoktystov, Artem Bennewitz, Roland Wenz, Gerhard Albrecht, Marcel Beilstein J Org Chem Full Research Paper Water-soluble shape-persistent cyclodextrin (CD) polymers with amino-functionalized end groups were prepared starting from diacetylene-modified cyclodextrin monomers by a combined Glaser coupling/click chemistry approach. Structural perfection of the neutral CD polymers and inclusion complex formation with ditopic and monotopic guest molecules were proven by MALDI–TOF and UV–vis measurements. Small-angle neutron and X-ray (SANS/SAXS) scattering experiments confirm the stiffness of the polymer chains with an apparent contour length of about 130 Å. Surface modification of planar silicon wafers as well as AFM tips was realized by covalent bound formation between the terminal amino groups of the CD polymer and a reactive isothiocyanate–silane monolayer. Atomic force measurements of CD polymer decorated surfaces show enhanced supramolecular interaction energies which can be attributed to multiple inclusion complexes based on the rigidity of the polymer backbone and the regular configuration of the CD moieties. Depending on the geometrical configuration of attachment anisotropic adhesion characteristics of the polymer system can be distinguished between a peeling and a shearing mechanism. Beilstein-Institut 2017-05-18 /pmc/articles/PMC5480325/ /pubmed/28684975 http://dx.doi.org/10.3762/bjoc.13.95 Text en Copyright © 2017, Blass et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Full Research Paper Blass, Johanna Brunke, Jessica Emmerich, Franziska Przybylski, Cédric Garamus, Vasil M Feoktystov, Artem Bennewitz, Roland Wenz, Gerhard Albrecht, Marcel Interactions between shape-persistent macromolecules as probed by AFM |
title | Interactions between shape-persistent macromolecules as probed by AFM |
title_full | Interactions between shape-persistent macromolecules as probed by AFM |
title_fullStr | Interactions between shape-persistent macromolecules as probed by AFM |
title_full_unstemmed | Interactions between shape-persistent macromolecules as probed by AFM |
title_short | Interactions between shape-persistent macromolecules as probed by AFM |
title_sort | interactions between shape-persistent macromolecules as probed by afm |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480325/ https://www.ncbi.nlm.nih.gov/pubmed/28684975 http://dx.doi.org/10.3762/bjoc.13.95 |
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