Cargando…
Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making
BACKGROUND: The effects of acute tryptophan depletion on human decision-making suggest that serotonin modulates the processing of rewards and punishments. However, few studies have assessed which of the many types of serotonin receptors are responsible. METHODS: Using a within-subject, double-blind,...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480594/ https://www.ncbi.nlm.nih.gov/pubmed/27638901 http://dx.doi.org/10.1093/ijnp/pyw075 |
_version_ | 1783245292688113664 |
---|---|
author | Faulkner, Paul Mancinelli, Federico Lockwood, Patricia L Matarin, Mar Dolan, Raymond J Wood, Nick W Dayan, Peter Roiser, Jonathan P |
author_facet | Faulkner, Paul Mancinelli, Federico Lockwood, Patricia L Matarin, Mar Dolan, Raymond J Wood, Nick W Dayan, Peter Roiser, Jonathan P |
author_sort | Faulkner, Paul |
collection | PubMed |
description | BACKGROUND: The effects of acute tryptophan depletion on human decision-making suggest that serotonin modulates the processing of rewards and punishments. However, few studies have assessed which of the many types of serotonin receptors are responsible. METHODS: Using a within-subject, double-blind, sham-controlled design in 26 subjects, we examined whether individual differences in serotonin system gene transcription, measured in peripheral blood, predicted the effect of acute tryptophan depletion on decision-making. Participants performed a task in which they chose between successive pairs of fixed, lower-stakes (control) and variable, higher-stakes (experimental) gambles, each involving wins or losses. In 21 participants, mRNA from 9 serotonin system genes was measured in whole blood prior to acute tryptophan depletion: 5-HT1B, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT3A, 5-HT3E, 5-HT7 (serotonin receptors), 5-HTT (the serotonin transporter), and tryptophan hydroxylase 1. RESULTS: Acute tryptophan depletion did not significantly influence participants’ sensitivity to probability, wins, or losses, although there was a trend for a lower tendency to choose experimental gambles overall following depletion. Significant positive correlations, which survived correction for multiple comparisons, were detected between baseline 5-HT1B mRNA levels and acute tryptophan depletion-induced increases in both the overall tendency to choose the experimental gamble and sensitivity to wins. No significant relationship was observed with any other peripheral serotonin system markers. Computational analyses of decision-making data provided results consistent with these findings. CONCLUSIONS: These results suggest that the 5-HT1B receptor may modulate the effects of acute tryptophan depletion on risky decision-making. Peripheral levels of serotonin markers may predict response to treatments that act upon the serotonin system, such as selective serotonin reuptake inhibitors. |
format | Online Article Text |
id | pubmed-5480594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-54805942017-09-04 Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making Faulkner, Paul Mancinelli, Federico Lockwood, Patricia L Matarin, Mar Dolan, Raymond J Wood, Nick W Dayan, Peter Roiser, Jonathan P Int J Neuropsychopharmacol Regular Research Article BACKGROUND: The effects of acute tryptophan depletion on human decision-making suggest that serotonin modulates the processing of rewards and punishments. However, few studies have assessed which of the many types of serotonin receptors are responsible. METHODS: Using a within-subject, double-blind, sham-controlled design in 26 subjects, we examined whether individual differences in serotonin system gene transcription, measured in peripheral blood, predicted the effect of acute tryptophan depletion on decision-making. Participants performed a task in which they chose between successive pairs of fixed, lower-stakes (control) and variable, higher-stakes (experimental) gambles, each involving wins or losses. In 21 participants, mRNA from 9 serotonin system genes was measured in whole blood prior to acute tryptophan depletion: 5-HT1B, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT3A, 5-HT3E, 5-HT7 (serotonin receptors), 5-HTT (the serotonin transporter), and tryptophan hydroxylase 1. RESULTS: Acute tryptophan depletion did not significantly influence participants’ sensitivity to probability, wins, or losses, although there was a trend for a lower tendency to choose experimental gambles overall following depletion. Significant positive correlations, which survived correction for multiple comparisons, were detected between baseline 5-HT1B mRNA levels and acute tryptophan depletion-induced increases in both the overall tendency to choose the experimental gamble and sensitivity to wins. No significant relationship was observed with any other peripheral serotonin system markers. Computational analyses of decision-making data provided results consistent with these findings. CONCLUSIONS: These results suggest that the 5-HT1B receptor may modulate the effects of acute tryptophan depletion on risky decision-making. Peripheral levels of serotonin markers may predict response to treatments that act upon the serotonin system, such as selective serotonin reuptake inhibitors. Oxford University Press 2016-09-16 /pmc/articles/PMC5480594/ /pubmed/27638901 http://dx.doi.org/10.1093/ijnp/pyw075 Text en © The Author 2016. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular Research Article Faulkner, Paul Mancinelli, Federico Lockwood, Patricia L Matarin, Mar Dolan, Raymond J Wood, Nick W Dayan, Peter Roiser, Jonathan P Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making |
title | Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making |
title_full | Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making |
title_fullStr | Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making |
title_full_unstemmed | Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making |
title_short | Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making |
title_sort | peripheral serotonin 1b receptor transcription predicts the effect of acute tryptophan depletion on risky decision-making |
topic | Regular Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480594/ https://www.ncbi.nlm.nih.gov/pubmed/27638901 http://dx.doi.org/10.1093/ijnp/pyw075 |
work_keys_str_mv | AT faulknerpaul peripheralserotonin1breceptortranscriptionpredictstheeffectofacutetryptophandepletiononriskydecisionmaking AT mancinellifederico peripheralserotonin1breceptortranscriptionpredictstheeffectofacutetryptophandepletiononriskydecisionmaking AT lockwoodpatricial peripheralserotonin1breceptortranscriptionpredictstheeffectofacutetryptophandepletiononriskydecisionmaking AT matarinmar peripheralserotonin1breceptortranscriptionpredictstheeffectofacutetryptophandepletiononriskydecisionmaking AT dolanraymondj peripheralserotonin1breceptortranscriptionpredictstheeffectofacutetryptophandepletiononriskydecisionmaking AT woodnickw peripheralserotonin1breceptortranscriptionpredictstheeffectofacutetryptophandepletiononriskydecisionmaking AT dayanpeter peripheralserotonin1breceptortranscriptionpredictstheeffectofacutetryptophandepletiononriskydecisionmaking AT roiserjonathanp peripheralserotonin1breceptortranscriptionpredictstheeffectofacutetryptophandepletiononriskydecisionmaking |