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Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate
This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a si...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480779/ https://www.ncbi.nlm.nih.gov/pubmed/28757883 http://dx.doi.org/10.2217/pme-2016-0047 |
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author | Camporesi, Silvia Cavaliere, Giulia |
author_facet | Camporesi, Silvia Cavaliere, Giulia |
author_sort | Camporesi, Silvia |
collection | PubMed |
description | This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a significant break with the past. We discuss the ethical issues arising from CRISPR applications beyond human embryos, namely the use of gene drive-engineered mosquitoes to eradicate diseases, engineering nonhuman animals to harvest organs for human transplant and engineering crops. We discuss the experiments that have demonstrated the technical feasibility of cultivating embryos in vitro for up to 14 days, and possibly beyond this limit, and the ethical issues arising from the proposal to extend the limit beyond 14 days. |
format | Online Article Text |
id | pubmed-5480779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54807792017-09-19 Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate Camporesi, Silvia Cavaliere, Giulia Per Med Perspective This paper provides an overview of the ethical issues in the international clustered regularly interspaced short palindromic repeats (CRISPR) genome editing debate from March 2015 to September 2016. We present the regulatory framework for embryo research in the UK, and explain why CRISPR is not a significant break with the past. We discuss the ethical issues arising from CRISPR applications beyond human embryos, namely the use of gene drive-engineered mosquitoes to eradicate diseases, engineering nonhuman animals to harvest organs for human transplant and engineering crops. We discuss the experiments that have demonstrated the technical feasibility of cultivating embryos in vitro for up to 14 days, and possibly beyond this limit, and the ethical issues arising from the proposal to extend the limit beyond 14 days. Future Medicine Ltd 2016-11 2016-10-28 /pmc/articles/PMC5480779/ /pubmed/28757883 http://dx.doi.org/10.2217/pme-2016-0047 Text en © Silvia Camporesi This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Perspective Camporesi, Silvia Cavaliere, Giulia Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate |
title | Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate |
title_full | Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate |
title_fullStr | Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate |
title_full_unstemmed | Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate |
title_short | Emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate |
title_sort | emerging ethical perspectives in the clustered regularly interspaced short palindromic repeats genome-editing debate |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480779/ https://www.ncbi.nlm.nih.gov/pubmed/28757883 http://dx.doi.org/10.2217/pme-2016-0047 |
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