Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched for positive selection signals...

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Detalles Bibliográficos
Autores principales: Byars, Sean G., Huang, Qin Qin, Gray, Lesley-Ann, Bakshi, Andrew, Ripatti, Samuli, Abraham, Gad, Stearns, Stephen C., Inouye, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480811/
https://www.ncbi.nlm.nih.gov/pubmed/28640878
http://dx.doi.org/10.1371/journal.pgen.1006328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480811/
https://www.ncbi.nlm.nih.gov/pubmed/28640878
http://dx.doi.org/10.1371/journal.pgen.1006328

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