Cargando…

Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment

ABSTRACT: The antiparasitic activity and preliminary in vitro and in silico drug metabolism and pharmacokinetic (DMPK) assessment of six isomeric sesquiterpenes (1–6), isolated from the Cameroonian spice Scleria striatinux De Wild (Cyperaceae) is reported. The study was prompted by the observation t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nyongbela, Kennedy D., Ntie-Kang, Fidele, Hoye, Thomas R., Efange, Simon M. N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481270/ https://www.ncbi.nlm.nih.gov/pubmed/28421410 http://dx.doi.org/10.1007/s13659-017-0125-y

Ejemplares similares

Bioassay-guided discovery of antibacterial agents: in vitro screening of Peperomia vulcanica, Peperomia fernandopoioana and Scleria striatinux
por: Mbah, James A, et al.
Publicado: (2012)

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

In Vitro and In Vivo antifungal activities of selected Cameroonian dietary spices
por: Dzoyem, Jean Paul, et al.
Publicado: (2014)

CamMedNP: Building the Cameroonian 3D structural natural products database for virtual screening
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

Antiparasitic treatment using herbs and spices: A review of the literature of the phytotherapy
por: Strothmann, Adriane Leites, et al.
Publicado: (2022)

An in silico evaluation of the ADMET profile of the StreptomeDB database
por: Ntie-Kang, Fidele
Publicado: (2013)

4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies
por: Ikome, Hermia N., et al.
Publicado: (2016)

Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes
por: Fankam, Aimé G, et al.
Publicado: (2011)

In-silico Leishmania Target Selectivity of Antiparasitic Terpenoids
por: Ogungbe, Ifedayo Victor, et al.
Publicado: (2013)

Assessing the pharmacokinetic profile of the CamMedNP natural products database: an in silico approach
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

Molecular phylogenetic study of Scleria subgenus Hypoporum (Sclerieae, Cyperoideae, Cyperaceae) reveals several species new to science
por: Bauters, Kenneth, et al.
Publicado: (2018)

In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

Effect of spices formulations on the physicochemical and sensory properties of Nnam gon, a Cameroonian dish prepared with cucurbitaceae seeds
por: Manejo Djiogue, Josiane E., et al.
Publicado: (2016)

Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells
por: Atchan Nwakiban, Achille Parfait, et al.
Publicado: (2021)

Expanded DMPK repeats in dizygotic twins referred for diagnosis of autism versus absence of expanded DMPK repeats at screening of 330 children with autism
por: Musova, Zuzana, et al.
Publicado: (2016)

Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood
por: Buckley, Lauren, et al.
Publicado: (2016)

Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone
por: Imperatore, Concetta, et al.
Publicado: (2020)

Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
por: Voukeng, Igor K, et al.
Publicado: (2012)

Oxidative Stress Modulation by Cameroonian Spice Extracts in HepG2 Cells: Involvement of Nrf2 and Improvement of Glucose Uptake
por: Atchan Nwakiban, Achille Parfait, et al.
Publicado: (2020)

Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum
por: Ngemenya, Moses N., et al.
Publicado: (2018)

Antiparasitic activity of furanyl N-acylhydrazone derivatives against Trichomonas vaginalis: in vitro and in silico analyses
por: Alves, Mirna Samara Dié, et al.
Publicado: (2020)

Antiparasitic effect of Farnesol against Leishmania major: A rationale from in vitro and in silico investigations
por: Sharma, Harshita, et al.
Publicado: (2023)

Anti-onchocerca Metabolites from Cyperus articulatus: Isolation, In Vitro Activity and In Silico ‘Drug-Likeness’
por: Metuge, Jonathan Alunge, et al.
Publicado: (2014)

A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings
por: Nayim, Paul, et al.
Publicado: (2020)

Cooperation meets competition in microRNA-mediated DMPK transcript regulation
por: Koscianska, Edyta, et al.
Publicado: (2015)

DMPK mRNA Expression in Human Brain Tissue Throughout the Lifespan
por: Langbehn, Kathleen E., et al.
Publicado: (2020)

DMPK hypermethylation in sperm cells of myotonic dystrophy type 1 patients
por: Yanovsky-Dagan, Shira, et al.
Publicado: (2021)

Free radicals quenching potential, protective properties against oxidative mediated ion toxicity and HPLC phenolic profile of a Cameroonian spice: Piper guineensis
por: Moukette Moukette, Bruno, et al.
Publicado: (2015)

In silico investigation of phytoconstituents from Cameroonian medicinal plants towards COVID-19 treatment
por: Chtita, Samir, et al.
Publicado: (2022)

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence
por: Di Sotto, Antonella, et al.
Publicado: (2020)

New Antimalarial Hits from Dacryodes edulis (Burseraceae) - Part I: Isolation, In Vitro Activity, In Silico “drug-likeness” and Pharmacokinetic Profiles
por: Zofou, Denis, et al.
Publicado: (2013)

Artemisia herba-alba sesquiterpenes: in silico inhibition in the ATP-binding pocket
por: Mohamed, Tarik A., et al.
Publicado: (2023)

Role of Myotonic Dystrophy Protein Kinase (DMPK) in Glucose Homeostasis and Muscle Insulin Action
por: Llagostera, Esther, et al.
Publicado: (2007)

Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development
por: Michel, Lise, et al.
Publicado: (2015)

DMPK gene DNA methylation levels are associated with muscular and respiratory profiles in DM1
por: Légaré, Cécilia, et al.
Publicado: (2019)

High Resolution Analysis of DMPK Hypermethylation and Repeat Interruptions in Myotonic Dystrophy Type 1
por: Rasmussen, Astrid, et al.
Publicado: (2022)

Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment
por: Xie, Jiashu, et al.
Publicado: (2021)

Ophthalmological findings in Cameroonian boxers
por: Kagmeni, Giles, et al.
Publicado: (2017)

Editorial to Special Issue—“Structure-Activity Relationships (SAR) of Natural Products”
por: Sippl, Wolfgang, et al.
Publicado: (2021)

In-Silico Analyses of Sesquiterpene-Related Compounds on Selected Leishmania Enzyme-Based Targets
por: Bernal, Freddy A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_heqhnju3oigejp6lifn2gmjtis