Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization

ABSTRACT: A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products. Both the 3,3′-pyrrolidonyl spirooxindoles and spiroindolin-2-one δ-lactones were smoothly obtained by the intramolecular...

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Detalles Bibliográficos
Autores principales: Wu, Ting, Pan, Zhiqiang, Xia, Chengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481276/
https://www.ncbi.nlm.nih.gov/pubmed/28484999
http://dx.doi.org/10.1007/s13659-017-0131-0
Descripción
Sumario:ABSTRACT: A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products. Both the 3,3′-pyrrolidonyl spirooxindoles and spiroindolin-2-one δ-lactones were smoothly obtained by the intramolecular Dieckmann cyclization of oxindoles in excellent yield under mild conditions. GRAPHICAL ABSTRACT: [Image: see text]

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