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Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis

This study evaluates the relationship between obstructive sleep apnea (OSA) and asthma. Literature search was carried out in several electronic databases and random effects meta-analyses were performed to obtain pooled estimates of the prevalence of OSA, OSA risk and sleep disordered breathing (SDB)...

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Autores principales: Kong, De-Lei, Qin, Zheng, Shen, Hui, Jin, Hong-Yu, Wang, Wei, Wang, Zan-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481327/
https://www.ncbi.nlm.nih.gov/pubmed/28642543
http://dx.doi.org/10.1038/s41598-017-04446-6
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author Kong, De-Lei
Qin, Zheng
Shen, Hui
Jin, Hong-Yu
Wang, Wei
Wang, Zan-Feng
author_facet Kong, De-Lei
Qin, Zheng
Shen, Hui
Jin, Hong-Yu
Wang, Wei
Wang, Zan-Feng
author_sort Kong, De-Lei
collection PubMed
description This study evaluates the relationship between obstructive sleep apnea (OSA) and asthma. Literature search was carried out in several electronic databases and random effects meta-analyses were performed to obtain pooled estimates of the prevalence of OSA, OSA risk and sleep disordered breathing (SDB) in asthma patients and pooled odds ratios of the prevalence between asthma and non-asthma patients. In adult asthma patients, the prevalence [95% confidence interval] of OSA, OSA risk, and SDB was 49.50 [36.39, 62.60] %, 27.50 [19.31, 35.69] %, and 19.65 [14.84, 24.46] % respectively. The odds of having OSA, OS risk and SDB by the asthma patients were 2.64 [1.76, 3.52], 3.73 [2.90, 4.57] and 1.73 [1.11, 2.36] times higher (p < 0.00001 for all) in asthma than in non-asthma patients, respectively. Adult asthma patients with OSA had significantly higher BMI in comparison with asthma patients without OSA. This study reveals that the prevalence of OSA in asthma patients is considerably higher; even higher than OSA risk and SDB. Sleep studies should be performed in asthma patients with symptoms suggestive of OSA/OSA risk/SDB.
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spelling pubmed-54813272017-06-26 Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis Kong, De-Lei Qin, Zheng Shen, Hui Jin, Hong-Yu Wang, Wei Wang, Zan-Feng Sci Rep Article This study evaluates the relationship between obstructive sleep apnea (OSA) and asthma. Literature search was carried out in several electronic databases and random effects meta-analyses were performed to obtain pooled estimates of the prevalence of OSA, OSA risk and sleep disordered breathing (SDB) in asthma patients and pooled odds ratios of the prevalence between asthma and non-asthma patients. In adult asthma patients, the prevalence [95% confidence interval] of OSA, OSA risk, and SDB was 49.50 [36.39, 62.60] %, 27.50 [19.31, 35.69] %, and 19.65 [14.84, 24.46] % respectively. The odds of having OSA, OS risk and SDB by the asthma patients were 2.64 [1.76, 3.52], 3.73 [2.90, 4.57] and 1.73 [1.11, 2.36] times higher (p < 0.00001 for all) in asthma than in non-asthma patients, respectively. Adult asthma patients with OSA had significantly higher BMI in comparison with asthma patients without OSA. This study reveals that the prevalence of OSA in asthma patients is considerably higher; even higher than OSA risk and SDB. Sleep studies should be performed in asthma patients with symptoms suggestive of OSA/OSA risk/SDB. Nature Publishing Group UK 2017-06-22 /pmc/articles/PMC5481327/ /pubmed/28642543 http://dx.doi.org/10.1038/s41598-017-04446-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kong, De-Lei
Qin, Zheng
Shen, Hui
Jin, Hong-Yu
Wang, Wei
Wang, Zan-Feng
Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis
title Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis
title_full Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis
title_fullStr Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis
title_full_unstemmed Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis
title_short Association of Obstructive Sleep Apnea with Asthma: A Meta-Analysis
title_sort association of obstructive sleep apnea with asthma: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481327/
https://www.ncbi.nlm.nih.gov/pubmed/28642543
http://dx.doi.org/10.1038/s41598-017-04446-6
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