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Predicting conformational ensembles and genome-wide transcription factor binding sites from DNA sequences

DNA shape is emerging as an important determinant of transcription factor binding beyond just the DNA sequence. The only tool for large scale DNA shape estimates, DNAshape was derived from Monte-Carlo simulations and predicts four broad and static DNA shape features, Propeller twist, Helical twist,...

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Detalles Bibliográficos
Autores principales:	Andrabi, Munazah, Hutchins, Andrew Paul, Miranda-Saavedra, Diego, Kono, Hidetoshi, Nussinov, Ruth, Mizuguchi, Kenji, Ahmad, Shandar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481346/ https://www.ncbi.nlm.nih.gov/pubmed/28642456 http://dx.doi.org/10.1038/s41598-017-03199-6

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