SLC4A11 depletion impairs NRF2 mediated antioxidant signaling and increases reactive oxygen species in human corneal endothelial cells during oxidative stress

Corneal endothelial dystrophy is a progressive disease with gradual loss of vision and characterized by degeneration and dysfunction of corneal endothelial cells. Mutations in SLC4A11, a Na(+) dependent OH(−) transporter, cause congenital hereditary endothelial dystrophy (CHED) and Fuchs’ endothelia...

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Detalles Bibliográficos
Autores principales: Guha, Sanjukta, Chaurasia, Sunita, Ramachandran, Charanya, Roy, Sanhita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481427/
https://www.ncbi.nlm.nih.gov/pubmed/28642546
http://dx.doi.org/10.1038/s41598-017-03654-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481427/
https://www.ncbi.nlm.nih.gov/pubmed/28642546
http://dx.doi.org/10.1038/s41598-017-03654-4

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