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Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population

Gout is a chronic disease resulting from elevated serum urate (SU). Previous genome-wide association studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few have been conducted for Chinese descent. Here, we try to extensively investigate whether these loci contribute to gou...

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Autores principales: Li, Zhiqiang, Zhou, Zhaowei, Hou, Xu, Lu, Dajiang, Yuan, Xuan, Lu, Jie, Wang, Can, Han, Lin, Cui, Lingling, Liu, Zhen, Chen, Jianhua, Cheng, Xiaoyu, Zhang, Keke, Ji, Jue, Jia, Zhaotong, Ma, Lidan, Xin, Ying, Liu, Tian, Yu, Qing, Ren, Wei, Wang, Xuefeng, Li, Xinde, Mi, Qing-Sheng, Shi, Yongyong, Li, Changgui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481433/
https://www.ncbi.nlm.nih.gov/pubmed/28642574
http://dx.doi.org/10.1038/s41598-017-04127-4
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author Li, Zhiqiang
Zhou, Zhaowei
Hou, Xu
Lu, Dajiang
Yuan, Xuan
Lu, Jie
Wang, Can
Han, Lin
Cui, Lingling
Liu, Zhen
Chen, Jianhua
Cheng, Xiaoyu
Zhang, Keke
Ji, Jue
Jia, Zhaotong
Ma, Lidan
Xin, Ying
Liu, Tian
Yu, Qing
Ren, Wei
Wang, Xuefeng
Li, Xinde
Mi, Qing-Sheng
Shi, Yongyong
Li, Changgui
author_facet Li, Zhiqiang
Zhou, Zhaowei
Hou, Xu
Lu, Dajiang
Yuan, Xuan
Lu, Jie
Wang, Can
Han, Lin
Cui, Lingling
Liu, Zhen
Chen, Jianhua
Cheng, Xiaoyu
Zhang, Keke
Ji, Jue
Jia, Zhaotong
Ma, Lidan
Xin, Ying
Liu, Tian
Yu, Qing
Ren, Wei
Wang, Xuefeng
Li, Xinde
Mi, Qing-Sheng
Shi, Yongyong
Li, Changgui
author_sort Li, Zhiqiang
collection PubMed
description Gout is a chronic disease resulting from elevated serum urate (SU). Previous genome-wide association studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few have been conducted for Chinese descent. Here, we try to extensively investigate whether these loci contribute to gout risk in Han Chinese. A total of 2255 variants in linkage disequilibrium (LD) with GWAS identified SU/gout associated variants were analyzed in a Han Chinese cohort of 1255 gout patients and 1848 controls. Cumulative genetic risk score analysis was performed to assess the cumulative effect of multiple “risk” variants on gout incidence. 23 variants (41%) of LD pruned variants set (n = 56) showed nominal association with gout in our sample (p < 0.05). Some of the previously reported gout associated loci (except ALDH16A1), including ABCG2, SLC2A9, GCKR, ALDH2 and CNIH2, were replicated. Cumulative genetic risk score analyses showed that the risk of gout increased for individuals with the growing number (≥8) of the risk alleles on gout associated loci. Most of the gout associated loci identified in previous GWAS were confirmed in an independent Chinese cohort, and the SU associated loci also confer susceptibility to gout. These findings provide important information of the genetic association of gout.
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spelling pubmed-54814332017-06-26 Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population Li, Zhiqiang Zhou, Zhaowei Hou, Xu Lu, Dajiang Yuan, Xuan Lu, Jie Wang, Can Han, Lin Cui, Lingling Liu, Zhen Chen, Jianhua Cheng, Xiaoyu Zhang, Keke Ji, Jue Jia, Zhaotong Ma, Lidan Xin, Ying Liu, Tian Yu, Qing Ren, Wei Wang, Xuefeng Li, Xinde Mi, Qing-Sheng Shi, Yongyong Li, Changgui Sci Rep Article Gout is a chronic disease resulting from elevated serum urate (SU). Previous genome-wide association studies (GWAS) have identified dozens of susceptibility loci for SU/gout, but few have been conducted for Chinese descent. Here, we try to extensively investigate whether these loci contribute to gout risk in Han Chinese. A total of 2255 variants in linkage disequilibrium (LD) with GWAS identified SU/gout associated variants were analyzed in a Han Chinese cohort of 1255 gout patients and 1848 controls. Cumulative genetic risk score analysis was performed to assess the cumulative effect of multiple “risk” variants on gout incidence. 23 variants (41%) of LD pruned variants set (n = 56) showed nominal association with gout in our sample (p < 0.05). Some of the previously reported gout associated loci (except ALDH16A1), including ABCG2, SLC2A9, GCKR, ALDH2 and CNIH2, were replicated. Cumulative genetic risk score analyses showed that the risk of gout increased for individuals with the growing number (≥8) of the risk alleles on gout associated loci. Most of the gout associated loci identified in previous GWAS were confirmed in an independent Chinese cohort, and the SU associated loci also confer susceptibility to gout. These findings provide important information of the genetic association of gout. Nature Publishing Group UK 2017-06-22 /pmc/articles/PMC5481433/ /pubmed/28642574 http://dx.doi.org/10.1038/s41598-017-04127-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Zhiqiang
Zhou, Zhaowei
Hou, Xu
Lu, Dajiang
Yuan, Xuan
Lu, Jie
Wang, Can
Han, Lin
Cui, Lingling
Liu, Zhen
Chen, Jianhua
Cheng, Xiaoyu
Zhang, Keke
Ji, Jue
Jia, Zhaotong
Ma, Lidan
Xin, Ying
Liu, Tian
Yu, Qing
Ren, Wei
Wang, Xuefeng
Li, Xinde
Mi, Qing-Sheng
Shi, Yongyong
Li, Changgui
Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population
title Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population
title_full Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population
title_fullStr Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population
title_full_unstemmed Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population
title_short Replication of Gout/Urate Concentrations GWAS Susceptibility Loci Associated with Gout in a Han Chinese Population
title_sort replication of gout/urate concentrations gwas susceptibility loci associated with gout in a han chinese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481433/
https://www.ncbi.nlm.nih.gov/pubmed/28642574
http://dx.doi.org/10.1038/s41598-017-04127-4
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