The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function

Inositol 1,3,4,5,6-pentakisphosphate 2-kinases (IP(5) 2-Ks) are part of a family of enzymes in charge of synthesizing inositol hexakisphosphate (IP(6)) in eukaryotic cells. This protein and its product IP(6) present many roles in cells, participating in mRNA export, embryonic development, and apopto...

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Detalles Bibliográficos
Autores principales: Franco-Echevarría, Elsa, Sanz-Aparicio, Julia, Brearley, Charles A., González-Rubio, Juana M., González, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481561/
https://www.ncbi.nlm.nih.gov/pubmed/28450399
http://dx.doi.org/10.1074/jbc.M117.780395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481561/
https://www.ncbi.nlm.nih.gov/pubmed/28450399
http://dx.doi.org/10.1074/jbc.M117.780395

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