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Defects in the first wave of folliculogenesis in mouse XO ovaries

In mouse ovaries, the first wave of folliculogenesis perinatally starts near the medullary region, which directs the initial round of follicular growth soon after birth. At the same time, cortical primordial follicles start forming in the ovarian surface region, and then some are cyclically recruite...

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Autores principales: MIURA, Kento, MURATA, Chiharu, HARIKAE, Kyoko, SUZUKI, Hitomi, KANAI-AZUMA, Masami, KUROHMARU, Masamichi, TSUNEKAWA, Naoki, KANAI, Yoshiakira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481637/
https://www.ncbi.nlm.nih.gov/pubmed/28392504
http://dx.doi.org/10.1262/jrd.2017-033
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author MIURA, Kento
MURATA, Chiharu
HARIKAE, Kyoko
SUZUKI, Hitomi
KANAI-AZUMA, Masami
KUROHMARU, Masamichi
TSUNEKAWA, Naoki
KANAI, Yoshiakira
author_facet MIURA, Kento
MURATA, Chiharu
HARIKAE, Kyoko
SUZUKI, Hitomi
KANAI-AZUMA, Masami
KUROHMARU, Masamichi
TSUNEKAWA, Naoki
KANAI, Yoshiakira
author_sort MIURA, Kento
collection PubMed
description In mouse ovaries, the first wave of folliculogenesis perinatally starts near the medullary region, which directs the initial round of follicular growth soon after birth. At the same time, cortical primordial follicles start forming in the ovarian surface region, and then some are cyclically recruited for the second and subsequent rounds of follicular growth. Recent studies suggest different dynamics between the first and subsequent waves of follicular growth in postnatal ovaries. However, the phenotypic differences between these phases remain unclear. Here, we show direct evidence that XO female mice, a murine model for Turner Syndrome, lack the first wave of folliculogenesis. Our histopathological analyses of XX and XO littermates revealed a lack of anti-Müllerian hormone (AMH)-positive primary follicles in the XO ovaries by 4 days post partum (dpp). This loss of first follicles was also confirmed by histological bioassay for SRY-dependent SOX9 inducibility, a specific marker for the first follicular granulosa cells. In contrast, cortical primordial follicles formed properly in XO ovaries, and some of them formed primary and secondary follicles in the subcortical region by 7 dpp. They rapidly developed into late antral follicles, showing similarities to XX littermate ovaries by 21 dpp. These results suggest distinct X-monosomy effects between the first and subsequent waves of follicular growth, highlighting the high susceptibility to elimination of XO oocytes in the first wave of mammalian folliculogenesis.
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spelling pubmed-54816372017-06-27 Defects in the first wave of folliculogenesis in mouse XO ovaries MIURA, Kento MURATA, Chiharu HARIKAE, Kyoko SUZUKI, Hitomi KANAI-AZUMA, Masami KUROHMARU, Masamichi TSUNEKAWA, Naoki KANAI, Yoshiakira J Reprod Dev Original Article In mouse ovaries, the first wave of folliculogenesis perinatally starts near the medullary region, which directs the initial round of follicular growth soon after birth. At the same time, cortical primordial follicles start forming in the ovarian surface region, and then some are cyclically recruited for the second and subsequent rounds of follicular growth. Recent studies suggest different dynamics between the first and subsequent waves of follicular growth in postnatal ovaries. However, the phenotypic differences between these phases remain unclear. Here, we show direct evidence that XO female mice, a murine model for Turner Syndrome, lack the first wave of folliculogenesis. Our histopathological analyses of XX and XO littermates revealed a lack of anti-Müllerian hormone (AMH)-positive primary follicles in the XO ovaries by 4 days post partum (dpp). This loss of first follicles was also confirmed by histological bioassay for SRY-dependent SOX9 inducibility, a specific marker for the first follicular granulosa cells. In contrast, cortical primordial follicles formed properly in XO ovaries, and some of them formed primary and secondary follicles in the subcortical region by 7 dpp. They rapidly developed into late antral follicles, showing similarities to XX littermate ovaries by 21 dpp. These results suggest distinct X-monosomy effects between the first and subsequent waves of follicular growth, highlighting the high susceptibility to elimination of XO oocytes in the first wave of mammalian folliculogenesis. The Society for Reproduction and Development 2017-04-10 2017-06 /pmc/articles/PMC5481637/ /pubmed/28392504 http://dx.doi.org/10.1262/jrd.2017-033 Text en ©2017 Society for Reproduction and Development This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Article
MIURA, Kento
MURATA, Chiharu
HARIKAE, Kyoko
SUZUKI, Hitomi
KANAI-AZUMA, Masami
KUROHMARU, Masamichi
TSUNEKAWA, Naoki
KANAI, Yoshiakira
Defects in the first wave of folliculogenesis in mouse XO ovaries
title Defects in the first wave of folliculogenesis in mouse XO ovaries
title_full Defects in the first wave of folliculogenesis in mouse XO ovaries
title_fullStr Defects in the first wave of folliculogenesis in mouse XO ovaries
title_full_unstemmed Defects in the first wave of folliculogenesis in mouse XO ovaries
title_short Defects in the first wave of folliculogenesis in mouse XO ovaries
title_sort defects in the first wave of folliculogenesis in mouse xo ovaries
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481637/
https://www.ncbi.nlm.nih.gov/pubmed/28392504
http://dx.doi.org/10.1262/jrd.2017-033
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