Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy

Most studies have considered the negative influence of obesity on fertility in both genders. In the present study, we assessed mitochondrial activity expressed as the mitochondrial potential index (MPI) in cumulus cells from obese women and women with a normal body mass index (BMI) during assisted r...

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Autores principales: Gorshinova, Victoria K., Tsvirkun, Daria V., Sukhanova, Iuliia A., Tarasova, Nadezhda V., Volodina, Maria A., Marey, Maria V., Smolnikova, Veronika U., Vysokikh, Mikhail Yu., Sukhikh, Gennady T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481670/
https://www.ncbi.nlm.nih.gov/pubmed/28660134
http://dx.doi.org/10.1016/j.bbacli.2017.03.005
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author Gorshinova, Victoria K.
Tsvirkun, Daria V.
Sukhanova, Iuliia A.
Tarasova, Nadezhda V.
Volodina, Maria A.
Marey, Maria V.
Smolnikova, Veronika U.
Vysokikh, Mikhail Yu.
Sukhikh, Gennady T.
author_facet Gorshinova, Victoria K.
Tsvirkun, Daria V.
Sukhanova, Iuliia A.
Tarasova, Nadezhda V.
Volodina, Maria A.
Marey, Maria V.
Smolnikova, Veronika U.
Vysokikh, Mikhail Yu.
Sukhikh, Gennady T.
author_sort Gorshinova, Victoria K.
collection PubMed
description Most studies have considered the negative influence of obesity on fertility in both genders. In the present study, we assessed mitochondrial activity expressed as the mitochondrial potential index (MPI) in cumulus cells from obese women and women with a normal body mass index (BMI) during assisted reproductive therapy. The results revealed a significant reduction of MPI with increased body mass. The lower MPI levels in cumulus cells from obese women may reflect mitochondrial dysfunction caused by oxidative stress, which can affect the cumulus-oocyte complex and have an impact on oocyte development.
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spelling pubmed-54816702017-06-28 Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy Gorshinova, Victoria K. Tsvirkun, Daria V. Sukhanova, Iuliia A. Tarasova, Nadezhda V. Volodina, Maria A. Marey, Maria V. Smolnikova, Veronika U. Vysokikh, Mikhail Yu. Sukhikh, Gennady T. BBA Clin Regular Article Most studies have considered the negative influence of obesity on fertility in both genders. In the present study, we assessed mitochondrial activity expressed as the mitochondrial potential index (MPI) in cumulus cells from obese women and women with a normal body mass index (BMI) during assisted reproductive therapy. The results revealed a significant reduction of MPI with increased body mass. The lower MPI levels in cumulus cells from obese women may reflect mitochondrial dysfunction caused by oxidative stress, which can affect the cumulus-oocyte complex and have an impact on oocyte development. Elsevier 2017-04-05 /pmc/articles/PMC5481670/ /pubmed/28660134 http://dx.doi.org/10.1016/j.bbacli.2017.03.005 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Gorshinova, Victoria K.
Tsvirkun, Daria V.
Sukhanova, Iuliia A.
Tarasova, Nadezhda V.
Volodina, Maria A.
Marey, Maria V.
Smolnikova, Veronika U.
Vysokikh, Mikhail Yu.
Sukhikh, Gennady T.
Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy
title Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy
title_full Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy
title_fullStr Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy
title_full_unstemmed Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy
title_short Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy
title_sort cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481670/
https://www.ncbi.nlm.nih.gov/pubmed/28660134
http://dx.doi.org/10.1016/j.bbacli.2017.03.005
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