Diagnostic value of blood thiamine metabolites in Alzheimer’s disease examined by (11)C-PiB PET scanning

AIM: We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer’s disease (AD) by using positron emission tomography with (11)C-Pittsburgh compound B ((11)C-PiB PET) scanning. METHODS: Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabol...

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Detalles Bibliográficos
Autores principales: Chen, Zhichun, Pan, Xiaoli, Fei, Guoqiang, Pan, Shumei, Bao, Weiqi, Ren, Shuhua, Guan, Yihui, Zhong, Chunjiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2017
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481811/
https://www.ncbi.nlm.nih.gov/pubmed/28670464
http://dx.doi.org/10.4155/fsoa-2016-0087
Descripción
Sumario:AIM: We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer’s disease (AD) by using positron emission tomography with (11)C-Pittsburgh compound B ((11)C-PiB PET) scanning. METHODS: Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received (11)C-PiB PET scanning for the measurement of cerebral amyloid deposition. RESULTS: Thiamine diphosphate (TDP) had 66.7% sensitivity and 80.0% specificity for AD diagnosis, while the γ-value representing the best combination of thiamine metabolites and age had 24.2% sensitivity and 100.0% specificity according to the cut-off value of our previous study. CONCLUSION: Blood TDP but not γ-value exhibited results significant for AD diagnosis.

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