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Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review
BACKGROUND: In an effort to improve the screening and diagnosis of individuals with Fetal Alcohol Spectrum Disorder (FASD), research has focused on the identification of a unique neurodevelopmental profile characteristic of this population. The objective of this review was to identify any existing n...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481937/ https://www.ncbi.nlm.nih.gov/pubmed/28645298 http://dx.doi.org/10.1186/s40359-017-0191-2 |
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author | Lange, Shannon Rovet, Joanne Rehm, Jürgen Popova, Svetlana |
author_facet | Lange, Shannon Rovet, Joanne Rehm, Jürgen Popova, Svetlana |
author_sort | Lange, Shannon |
collection | PubMed |
description | BACKGROUND: In an effort to improve the screening and diagnosis of individuals with Fetal Alcohol Spectrum Disorder (FASD), research has focused on the identification of a unique neurodevelopmental profile characteristic of this population. The objective of this review was to identify any existing neurodevelopmental profiles of FASD and review their classification function in order to identify gaps and limitations of the current literature. METHODS: A systematic search for studies published up to the end of December 2016 reporting an identified neurodevelopmental profile of FASD was conducted using multiple electronic bibliographic databases. The search was not limited geographically or by language of publication. Original research published in a peer-reviewed journal that involved the evaluation of the classification function of an identified neurodevelopmental profile of FASD was included. RESULTS: Two approaches have been taken to determine the pathognomonic neurodevelopmental features of FASD, namely the utilization of i) behavioral observations/ratings by parents/caregivers and ii) subtest scores from standardized test batteries assessing a variety of neurodevelopmental domains. Both approaches show some promise, with the former approach (which is dominated by research on the Neurobehavioral Screening Tool) having good sensitivity (63% to 98%), but varying specificity (42% to 100%), and the latter approach having good specificity (72% to 96%), but varying sensitivity (60% to 88%). CONCLUSIONS: The current review revealed that research in this area remains limited and a definitive neurodevelopmental profile of FASD has not been established. However, the identification of a neurodevelopmental profile will aid in the accurate identification of individuals with FASD, by adding to the armamentarium of clinicians. The full review protocol is available in PROSPERO (http://www.crd.york.ac.uk/PROSPERO/); registration number CRD42016039326; registered 20 May 2016. |
format | Online Article Text |
id | pubmed-5481937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54819372017-06-26 Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review Lange, Shannon Rovet, Joanne Rehm, Jürgen Popova, Svetlana BMC Psychol Research Article BACKGROUND: In an effort to improve the screening and diagnosis of individuals with Fetal Alcohol Spectrum Disorder (FASD), research has focused on the identification of a unique neurodevelopmental profile characteristic of this population. The objective of this review was to identify any existing neurodevelopmental profiles of FASD and review their classification function in order to identify gaps and limitations of the current literature. METHODS: A systematic search for studies published up to the end of December 2016 reporting an identified neurodevelopmental profile of FASD was conducted using multiple electronic bibliographic databases. The search was not limited geographically or by language of publication. Original research published in a peer-reviewed journal that involved the evaluation of the classification function of an identified neurodevelopmental profile of FASD was included. RESULTS: Two approaches have been taken to determine the pathognomonic neurodevelopmental features of FASD, namely the utilization of i) behavioral observations/ratings by parents/caregivers and ii) subtest scores from standardized test batteries assessing a variety of neurodevelopmental domains. Both approaches show some promise, with the former approach (which is dominated by research on the Neurobehavioral Screening Tool) having good sensitivity (63% to 98%), but varying specificity (42% to 100%), and the latter approach having good specificity (72% to 96%), but varying sensitivity (60% to 88%). CONCLUSIONS: The current review revealed that research in this area remains limited and a definitive neurodevelopmental profile of FASD has not been established. However, the identification of a neurodevelopmental profile will aid in the accurate identification of individuals with FASD, by adding to the armamentarium of clinicians. The full review protocol is available in PROSPERO (http://www.crd.york.ac.uk/PROSPERO/); registration number CRD42016039326; registered 20 May 2016. BioMed Central 2017-06-23 /pmc/articles/PMC5481937/ /pubmed/28645298 http://dx.doi.org/10.1186/s40359-017-0191-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lange, Shannon Rovet, Joanne Rehm, Jürgen Popova, Svetlana Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review |
title | Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review |
title_full | Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review |
title_fullStr | Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review |
title_full_unstemmed | Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review |
title_short | Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review |
title_sort | neurodevelopmental profile of fetal alcohol spectrum disorder: a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481937/ https://www.ncbi.nlm.nih.gov/pubmed/28645298 http://dx.doi.org/10.1186/s40359-017-0191-2 |
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