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High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast

Parkinson's disease (PD) is a common neurodegenerative disorder that affects ~2% of the human population aged >65. α-synuclein serves a role in the pathogenesis of PD as it is a primary component of Lewy bodies, a pathological feature of PD. Endosomal-lysosomal dysfunction may be a key facto...

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Detalles Bibliográficos
Autores principales:	Huang, Yi, Chen, Xiang, He, Xiaofei, Guo, Caifeng, Sun, Xicui, Liang, Fengyin, Long, Simei, Lu, Xilin, Feng, Luyang, Guo, Wenyuan, Zeng, Yixuan, Pei, Zhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482071/ https://www.ncbi.nlm.nih.gov/pubmed/28487947 http://dx.doi.org/10.3892/mmr.2017.6551

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