Regulatory B cells in infectious disease

Regulatory B cells (Bregs) are a subset of B cells, which reportedly exert significant immunomodulatory effects through the production of interleukin (IL)-10, IL-35 and transforming growth factor-β. Over the last decade, studies have indicated that Bregs function in autoimmune and allergic diseases through antigen-specific and non-specific immunoregulatory mechanisms. However, only a limited number of reviews have focused on the role of Bregs during infection, particularly their functions in intracellular infections. The present review discusses the role of Bregs in infectious diseases in animal models and human studies, and provides an overview of the immunoregulatory mechanisms used by Bregs.