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Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment

PURPOSE: Retinal detachment disrupts the rod-bipolar synapse in the outer plexiform layer by retraction of rod axons. We showed that breakage is due to RhoA activation whereas inhibition of Rho kinase (ROCK), using Y27632, reduces synaptic damage. We test whether the ROCK inhibitor fasudil, used for...

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Detalles Bibliográficos
Autores principales:	Townes-Anderson, Ellen, Wang, Jianfeng, Halász, Éva, Sugino, Ilene, Pitler, Amy, Whitehead, Ian, Zarbin, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482187/ https://www.ncbi.nlm.nih.gov/pubmed/28660097 http://dx.doi.org/10.1167/tvst.6.3.22

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