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Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching
OBJECTIVE: This randomized, controlled, double-blind clinical study evaluated the effect of calcium sodium phosphosilicate (NovaMin) and casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF) on the prevention of post-operative sensitivity and on the effects of clinical bleaching...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculdade De Odontologia De Bauru - USP
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482257/ https://www.ncbi.nlm.nih.gov/pubmed/28678953 http://dx.doi.org/10.1590/1678-7757-2016-0408 |
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author | ALEXANDRINO, Larissa Dias ALENCAR, Cristiane de Melo da SILVEIRA, Ana Daniela Silva ALVES, Eliane Bemerguy SILVA, Cecy Martins |
author_facet | ALEXANDRINO, Larissa Dias ALENCAR, Cristiane de Melo da SILVEIRA, Ana Daniela Silva ALVES, Eliane Bemerguy SILVA, Cecy Martins |
author_sort | ALEXANDRINO, Larissa Dias |
collection | PubMed |
description | OBJECTIVE: This randomized, controlled, double-blind clinical study evaluated the effect of calcium sodium phosphosilicate (NovaMin) and casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF) on the prevention of post-operative sensitivity and on the effects of clinical bleaching treatment. MATERIAL AND METHODS: Sixty volunteers were selected according to inclusion and exclusion criteria and were randomly assigned into three groups (n=20): CG (control group) patients, who were treated with 35% hydrogen peroxide; NOVAG (NovaMin group) patients, who were treated with 35% hydrogen peroxide followed by the application of NovaMin; and CPPG (CPP group) patients, who were treated with 35% hydrogen peroxide followed by the application of CPP-ACPF. Both bioactive agents were applied for five minutes. An evaporative stimulus associated with a modified visual scale was used to analyze sensitivity 24 hours after each bleaching session. The color evaluation was performed on the maxillary central incisors using a spectrophotometer. Associations between the intervention group, bleaching session, and reported sensitivity were tested using Chi-square partitioning. RESULTS: Color change values (ΔE) were analyzed using analysis of variance (ANOVA). The significance level used for both tests was 5%. In the intragroup assessment, the Friedman test showed that only the CPP-ACPF group showed no statistically significant difference (p<0.05) between baseline and first bleaching session. In the intergroup assessment, the Kruskal–Wallis test showed that the CPPG had less postoperative sensitivity after the first session, when compared to the other groups (p<0.05). Color change analysis (ΔE) showed a significant difference between the means obtained in the different bleaching sessions in all groups (p<0.05). CONCLUSIONS: This study showed that the combination of CPP-ACPF with 35% hydrogen peroxide significantly reduced post-operative sensitivity in the first session, compared with the other evaluated treatments. The association of CPP-ACPF and NovaMin did not affect the color change induced by tooth bleaching. |
format | Online Article Text |
id | pubmed-5482257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Faculdade De Odontologia De Bauru - USP |
record_format | MEDLINE/PubMed |
spelling | pubmed-54822572017-06-28 Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching ALEXANDRINO, Larissa Dias ALENCAR, Cristiane de Melo da SILVEIRA, Ana Daniela Silva ALVES, Eliane Bemerguy SILVA, Cecy Martins J Appl Oral Sci Original Articles OBJECTIVE: This randomized, controlled, double-blind clinical study evaluated the effect of calcium sodium phosphosilicate (NovaMin) and casein phosphopeptide-amorphous calcium phosphate with fluoride (CPP-ACPF) on the prevention of post-operative sensitivity and on the effects of clinical bleaching treatment. MATERIAL AND METHODS: Sixty volunteers were selected according to inclusion and exclusion criteria and were randomly assigned into three groups (n=20): CG (control group) patients, who were treated with 35% hydrogen peroxide; NOVAG (NovaMin group) patients, who were treated with 35% hydrogen peroxide followed by the application of NovaMin; and CPPG (CPP group) patients, who were treated with 35% hydrogen peroxide followed by the application of CPP-ACPF. Both bioactive agents were applied for five minutes. An evaporative stimulus associated with a modified visual scale was used to analyze sensitivity 24 hours after each bleaching session. The color evaluation was performed on the maxillary central incisors using a spectrophotometer. Associations between the intervention group, bleaching session, and reported sensitivity were tested using Chi-square partitioning. RESULTS: Color change values (ΔE) were analyzed using analysis of variance (ANOVA). The significance level used for both tests was 5%. In the intragroup assessment, the Friedman test showed that only the CPP-ACPF group showed no statistically significant difference (p<0.05) between baseline and first bleaching session. In the intergroup assessment, the Kruskal–Wallis test showed that the CPPG had less postoperative sensitivity after the first session, when compared to the other groups (p<0.05). Color change analysis (ΔE) showed a significant difference between the means obtained in the different bleaching sessions in all groups (p<0.05). CONCLUSIONS: This study showed that the combination of CPP-ACPF with 35% hydrogen peroxide significantly reduced post-operative sensitivity in the first session, compared with the other evaluated treatments. The association of CPP-ACPF and NovaMin did not affect the color change induced by tooth bleaching. Faculdade De Odontologia De Bauru - USP 2017 /pmc/articles/PMC5482257/ /pubmed/28678953 http://dx.doi.org/10.1590/1678-7757-2016-0408 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles ALEXANDRINO, Larissa Dias ALENCAR, Cristiane de Melo da SILVEIRA, Ana Daniela Silva ALVES, Eliane Bemerguy SILVA, Cecy Martins Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching |
title | Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching |
title_full | Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching |
title_fullStr | Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching |
title_full_unstemmed | Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching |
title_short | Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching |
title_sort | randomized clinical trial of the effect of novamin and cpp-acpf in combination with dental bleaching |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482257/ https://www.ncbi.nlm.nih.gov/pubmed/28678953 http://dx.doi.org/10.1590/1678-7757-2016-0408 |
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