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Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models
Acanthamoeba keratitis (AK) is a rare but sight-threatening disease caused by pathogenic species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to conta...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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YJBM
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482302/ https://www.ncbi.nlm.nih.gov/pubmed/28656012 |
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author | Neelam, Sudha Niederkorn, Jerry Y. |
author_facet | Neelam, Sudha Niederkorn, Jerry Y. |
author_sort | Neelam, Sudha |
collection | PubMed |
description | Acanthamoeba keratitis (AK) is a rare but sight-threatening disease caused by pathogenic species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to contaminated water and ocular trauma are also associated with AK. Once a patient develops AK the prognosis is very poor unless an aggressive treatment regimen is initiated early. Some of the intriguing features of AK are the lack of immunological memory, resistance of the dormant cyst form to treatment, differences between the pathogenic strains and soil isolates of Acanthamoeba and the unique role of the innate immune system in controlling this disease. Understanding the series of steps involved in the pathogenesis of the disease and the host immune response against Acanthamoeba antigens is crucial for developing effective therapeutic strategies targeting the disease. |
format | Online Article Text |
id | pubmed-5482302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | YJBM |
record_format | MEDLINE/PubMed |
spelling | pubmed-54823022017-06-27 Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models
Neelam, Sudha Niederkorn, Jerry Y. Yale J Biol Med Review Acanthamoeba keratitis (AK) is a rare but sight-threatening disease caused by pathogenic species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to contaminated water and ocular trauma are also associated with AK. Once a patient develops AK the prognosis is very poor unless an aggressive treatment regimen is initiated early. Some of the intriguing features of AK are the lack of immunological memory, resistance of the dormant cyst form to treatment, differences between the pathogenic strains and soil isolates of Acanthamoeba and the unique role of the innate immune system in controlling this disease. Understanding the series of steps involved in the pathogenesis of the disease and the host immune response against Acanthamoeba antigens is crucial for developing effective therapeutic strategies targeting the disease. YJBM 2017-06-23 /pmc/articles/PMC5482302/ /pubmed/28656012 Text en Copyright ©2017, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes. |
spellingShingle | Review Neelam, Sudha Niederkorn, Jerry Y. Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models |
title | Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models
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title_full | Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models
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title_fullStr | Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models
|
title_full_unstemmed | Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models
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title_short | Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Models
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title_sort | pathobiology and immunobiology of acanthamoeba keratitis: insights from animal models
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topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482302/ https://www.ncbi.nlm.nih.gov/pubmed/28656012 |
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