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Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs


Borrelia (Borreliella) burgdorferi and closely related genospecies are the causative agents of Lyme disease, the most common tick-borne disease north of the equator. The bacterium, a member of the spirochete phylum, is acquired by a tick vector that feeds on an infected vertebrate host and is transm...

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Autores principales: Lybecker, Meghan C., Samuels, D. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: YJBM 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482307/
https://www.ncbi.nlm.nih.gov/pubmed/28656017
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author Lybecker, Meghan C.
Samuels, D. Scott
author_facet Lybecker, Meghan C.
Samuels, D. Scott
author_sort Lybecker, Meghan C.
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description Borrelia (Borreliella) burgdorferi and closely related genospecies are the causative agents of Lyme disease, the most common tick-borne disease north of the equator. The bacterium, a member of the spirochete phylum, is acquired by a tick vector that feeds on an infected vertebrate host and is transmitted to another vertebrate during subsequent feeding by the next tick stage. The precise navigation of this enzootic cycle entails the regulation of genes required for these two host-specific phases as well as the transitions between them. Recently, an expansive swath of small RNAs has been identified in B. burgdorferi and likely many, if not most, are involved in regulating gene expression. Regardless, with only a few exceptions, the functions of these RNAs are completely unknown. However, several state-of-the-art approaches are available to identify the targets of these RNAs and provide insight into their role in the enzootic cycle and infection.
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spelling pubmed-54823072017-06-27 Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs
 Lybecker, Meghan C. Samuels, D. Scott Yale J Biol Med Review Borrelia (Borreliella) burgdorferi and closely related genospecies are the causative agents of Lyme disease, the most common tick-borne disease north of the equator. The bacterium, a member of the spirochete phylum, is acquired by a tick vector that feeds on an infected vertebrate host and is transmitted to another vertebrate during subsequent feeding by the next tick stage. The precise navigation of this enzootic cycle entails the regulation of genes required for these two host-specific phases as well as the transitions between them. Recently, an expansive swath of small RNAs has been identified in B. burgdorferi and likely many, if not most, are involved in regulating gene expression. Regardless, with only a few exceptions, the functions of these RNAs are completely unknown. However, several state-of-the-art approaches are available to identify the targets of these RNAs and provide insight into their role in the enzootic cycle and infection. YJBM 2017-06-23 /pmc/articles/PMC5482307/ /pubmed/28656017 Text en Copyright ©2017, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes.
spellingShingle Review
Lybecker, Meghan C.
Samuels, D. Scott
Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs

title Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs

title_full Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs

title_fullStr Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs

title_full_unstemmed Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs

title_short Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs

title_sort small rnas of borrelia burgdorferi: characterizing functional regulators in a sea of srnas

topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482307/
https://www.ncbi.nlm.nih.gov/pubmed/28656017
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