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Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs
Borrelia (Borreliella) burgdorferi and closely related genospecies are the causative agents of Lyme disease, the most common tick-borne disease north of the equator. The bacterium, a member of the spirochete phylum, is acquired by a tick vector that feeds on an infected vertebrate host and is transm...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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YJBM
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482307/ https://www.ncbi.nlm.nih.gov/pubmed/28656017 |
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author | Lybecker, Meghan C. Samuels, D. Scott |
author_facet | Lybecker, Meghan C. Samuels, D. Scott |
author_sort | Lybecker, Meghan C. |
collection | PubMed |
description | Borrelia (Borreliella) burgdorferi and closely related genospecies are the causative agents of Lyme disease, the most common tick-borne disease north of the equator. The bacterium, a member of the spirochete phylum, is acquired by a tick vector that feeds on an infected vertebrate host and is transmitted to another vertebrate during subsequent feeding by the next tick stage. The precise navigation of this enzootic cycle entails the regulation of genes required for these two host-specific phases as well as the transitions between them. Recently, an expansive swath of small RNAs has been identified in B. burgdorferi and likely many, if not most, are involved in regulating gene expression. Regardless, with only a few exceptions, the functions of these RNAs are completely unknown. However, several state-of-the-art approaches are available to identify the targets of these RNAs and provide insight into their role in the enzootic cycle and infection. |
format | Online Article Text |
id | pubmed-5482307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | YJBM |
record_format | MEDLINE/PubMed |
spelling | pubmed-54823072017-06-27 Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs
Lybecker, Meghan C. Samuels, D. Scott Yale J Biol Med Review Borrelia (Borreliella) burgdorferi and closely related genospecies are the causative agents of Lyme disease, the most common tick-borne disease north of the equator. The bacterium, a member of the spirochete phylum, is acquired by a tick vector that feeds on an infected vertebrate host and is transmitted to another vertebrate during subsequent feeding by the next tick stage. The precise navigation of this enzootic cycle entails the regulation of genes required for these two host-specific phases as well as the transitions between them. Recently, an expansive swath of small RNAs has been identified in B. burgdorferi and likely many, if not most, are involved in regulating gene expression. Regardless, with only a few exceptions, the functions of these RNAs are completely unknown. However, several state-of-the-art approaches are available to identify the targets of these RNAs and provide insight into their role in the enzootic cycle and infection. YJBM 2017-06-23 /pmc/articles/PMC5482307/ /pubmed/28656017 Text en Copyright ©2017, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes. |
spellingShingle | Review Lybecker, Meghan C. Samuels, D. Scott Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs |
title | Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs
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title_full | Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs
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title_fullStr | Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs
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title_full_unstemmed | Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs
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title_short | Small RNAs of Borrelia burgdorferi: Characterizing Functional Regulators in a Sea of sRNAs
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title_sort | small rnas of borrelia burgdorferi: characterizing functional regulators in a sea of srnas
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topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482307/ https://www.ncbi.nlm.nih.gov/pubmed/28656017 |
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